| 1. | ALA3624877 | A | Volume of distribution at steady state in ICR mouse at 1 mg/kg, iv | Mus musculus | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | organism-based format | Scientific Literature |
| 2. | ALA3624878 | A | AUC (0 to infinity) in ICR mouse at 1 mg/kg, iv | Mus musculus | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | organism-based format | Scientific Literature |
| 3. | ALA3624879 | A | Cmax in ICR mouse plasma at 10 mg/kg, po | Mus musculus | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | organism-based format | Scientific Literature |
| 4. | ALA3624880 | A | Elimination half-life in ICR mouse plasma at 10 mg/kg, po | Mus musculus | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | organism-based format | Scientific Literature |
| 5. | ALA3624881 | A | Oral bioavailability in ICR mouse at 10 mg/kg | Mus musculus | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | organism-based format | Scientific Literature |
| 6. | ALA3624882 | A | AUC (0 to infinity) in ICR mouse at 10 mg/kg, po | Mus musculus | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | organism-based format | Scientific Literature |
| 7. | ALA3624883 | F | Antitumor activity against human Caki1 cells xenografted in BALB/c nu mouse assessed as tumor growth inhibition at 1 mg/kg, po administered 5 times a week for 4 weeks measured after 42 days relative to control | Homo sapiens | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | organism-based format | Scientific Literature |
| 8. | ALA3624884 | F | Antitumor activity against human Caki1 cells xenografted in BALB/c nu mouse assessed as tumor growth inhibition at 3 mg/kg, po administered 5 times a week for 4 weeks measured after 42 days relative to control | Homo sapiens | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | organism-based format | Scientific Literature |
| 9. | ALA3624885 | F | Cell cycle arrest in human Caki1 cells assessed as accumulation at sub-G1 phase at 1000 pM after 24 hrs by flow cytometry (Rvb = 0.8%) | Homo sapiens | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | cell-based format | Scientific Literature |
| 10. | ALA3624886 | T | Toxicity in human Caki1 cells xenografted BALB/c nu mouse assessed as body weight change at 1 mg/kg, po administered 5 times a week for 4 weeks measured every 2 to 3 days | Mus musculus | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | organism-based format | Scientific Literature |
| 11. | ALA3624887 | T | Toxicity in human Caki1 cells xenografted BALB/c nu mouse assessed as body weight change at 3 mg/kg, po administered 5 times a week for 4 weeks measured every 2 to 3 days | Mus musculus | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | organism-based format | Scientific Literature |
| 12. | ALA3624888 | A | Overt toxicity in human Caki1 cells xenografted BALB/c nu mouse at 1 mg/kg, po administered 5 times a week for 4 weeks | Mus musculus | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | organism-based format | Scientific Literature |
| 13. | ALA3625007 | A | Overt toxicity in human Caki1 cells xenografted BALB/c nu mouse at 3 mg/kg, po administered 5 times a week for 4 weeks | Mus musculus | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | organism-based format | Scientific Literature |
| 14. | ALA3625008 | F | Antitumor activity against human Caki1 cells xenografted BALB/c-nu mouse assessed as down regulation of PCNA in tumor tissue at 1 to 3 mg/kg, po administered 5 times a week for 4 weeks by Western blot analysis | Homo sapiens | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | organism-based format | Scientific Literature |
| 15. | ALA3625009 | F | Antitumor activity against human Caki1 cells xenografted BALB/c-nu mouse assessed as down regulation of NNMT in tumor tissue at 1 to 3 mg/kg, po administered 5 times a week for 4 weeks by Western blot analysis | Homo sapiens | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | organism-based format | Scientific Literature |
| 16. | ALA3625010 | F | Antitumor activity against human Caki1 cells xenografted BALB/c-nu mouse assessed as up-regulation of phosphorylated JNK in tumor tissue at 1 to 3 mg/kg, po administered 5 times a week for 4 weeks by Western blot analysis | Homo sapiens | 1 | 26393416 10.1021/acs.jmedchem.5b00764 | organism-based format | Scientific Literature |
