Drug Mechanisms

#	Molecule Aladdin ID	Cas Number	Product Number	Parent Molecule Name	Parent Molecule Type	Mechanism of Action	Max Phase	First Approval	USAN Stem	Target Aladdin ID	Target Name	Action Type	Target Type	Target Organism	Binding Site Name	References
1.	Indinavir sulfate	157810-81-6	I303016	INDINAVIR SULFATE	Small molecule	Human immunodeficiency virus type 1 protease inhibitor	4.0	1996	-vir	ALA243	Human immunodeficiency virus type 1 protease	INHIBITOR	SINGLE PROTEIN	Human immunodeficiency virus 1		EMA: [1]
2.	ALA2096651			MANGAFODIPIR TRISODIUM	Small molecule	Diagnostic	4.0	1997				na	na	na		EMA: [1]
3.	Urea-¹³C	58069-82-2	U475802	UREA C 13	Small molecule	Diagnostic agent	4.0	1996				na	na	na		EMA: [1]
4.	ALA2108512			HEPATITIS B IMMUNE GLOBULIN	Unknown	Surface antigen (HBsAg) binding agent	4.0	2009	-bulin	ALA5308521	Surface antigen (HBsAg)	BINDING AGENT	SINGLE PROTEIN	Hepatitis B virus		EMA: [1]
5.	levomethadyl acetate	1477-40-3	L611510	LEVOMETHADYL ACETATE	Small molecule	Mu opioid receptor agonist	4.0	1993		ALA233	Mu opioid receptor	AGONIST	SINGLE PROTEIN	Homo sapiens		Other: [1]
6.	Perfluoro-n-pentane	678-26-2	P281758	PERFLENAPENT	Small molecule	Ultrasound contrast agent	4.0	1998				na	na	na		PubMed: [1]
7.	ALA5315125			DUVELISIB MONOHYDRATE	Small molecule	PI3-kinase p110-gamma subunit inhibitor	4.0	2018	-lisib	ALA3267	PI3-kinase p110-gamma subunit	INHIBITOR	SINGLE PROTEIN	Homo sapiens		EMA: [1]
8.	ALA5315125			DUVELISIB MONOHYDRATE	Small molecule	PI3-kinase p110-delta subunit inhibitor	4.0	2018	-lisib	ALA3130	PI3-kinase p110-delta subunit	INHIBITOR	SINGLE PROTEIN	Homo sapiens		EMA: [1]
9.	ALA5315123			DIFELIKEFALIN ACETATE	Protein	Kappa opioid receptor agonist	4.0	2021	-kef-	ALA237	Kappa opioid receptor	AGONIST	SINGLE PROTEIN	Homo sapiens		EMA: [1]
10.	ALA5315122			BORTEZOMIB D-MANNITOL	Small molecule	26S proteasome inhibitor	4.0	2015	-zomib	ALA2364701	26S proteasome	INHIBITOR	PROTEIN COMPLEX	Homo sapiens	Binds the chymotrypsin-like subunit of the proteasome	EMA: [1]
11.	ALA5315121			TECOVIRIMAT MONOHYDRATE	Small molecule	Envelope phospholipase OPG057 inhibitor	4.0	2018	-vir-	ALA5308523	Envelope phospholipase OPG057	INHIBITOR	SINGLE PROTEIN	Monkeypox virus		EMA: [1]
12.	ALA5315121			TECOVIRIMAT MONOHYDRATE	Small molecule	Envelope phospholipase OPG057 inhibitor	4.0	2018	-vir-	ALA5308524	Envelope phospholipase OPG057	INHIBITOR	SINGLE PROTEIN	Cowpox virus		EMA: [1]
13.	ALA5315120			ODEVIXIBAT SESQUIHYDRATE	Small molecule	Ileal bile acid transporter inhibitor	4.0	2021	-ixibat	ALA2778	Ileal bile acid transporter	INHIBITOR	SINGLE PROTEIN	Homo sapiens		EMA: [1]
14.	ALA5315119			UPADACITINIB HEMIHYDRATE	Small molecule	Tyrosine-protein kinase JAK1 inhibitor	4.0	2019	-tinib	ALA2835	Tyrosine-protein kinase JAK1	INHIBITOR	SINGLE PROTEIN	Homo sapiens		EMA: [1]
15.	ALA5315119			UPADACITINIB HEMIHYDRATE	Small molecule	Tyrosine-protein kinase JAK2 inhibitor	4.0	2019	-tinib	ALA2971	Tyrosine-protein kinase JAK2	INHIBITOR	SINGLE PROTEIN	Homo sapiens		EMA: [1]
16.	ALA5315119			UPADACITINIB HEMIHYDRATE	Small molecule	Tyrosine-protein kinase JAK3 inhibitor	4.0	2019	-tinib	ALA2148	Tyrosine-protein kinase JAK3	INHIBITOR	SINGLE PROTEIN	Homo sapiens		EMA: [1]
17.	ALA5315119			UPADACITINIB HEMIHYDRATE	Small molecule	Tyrosine-protein kinase TYK2 inhibitor	4.0	2019	-tinib	ALA3553	Tyrosine-protein kinase TYK2	INHIBITOR	SINGLE PROTEIN	Homo sapiens		EMA: [1]
18.	ALA5315118			ILOPROST TROMETHAMINE	Small molecule	Prostanoid IP receptor agonist	4.0	2003	-prost	ALA1995	Prostanoid IP receptor	AGONIST	SINGLE PROTEIN	Homo sapiens		EMA: [1]
19.	Doripenem Hydrate	364622-82-2	D423634	DORIPENEM MONOHYDRATE	Small molecule	Bacterial penicillin-binding protein inhibitor	4.0	2008	-penem	ALA2354204	Bacterial penicillin-binding protein	INHIBITOR	PROTEIN FAMILY	Bacteria		EMA: [1]
20.	ALA5315117			ZANAMIVIR HYDRATE	Small molecule	Neuraminidase inhibitor	4.0	2019	-vir	ALA6135	Neuraminidase	INHIBITOR	SINGLE PROTEIN	Influenza A virus		EMA: [1]