≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
2-Chloro-N-(hydroxymethyl)acetamide (N-methylolchloracetamide) is a N-hydroxymethyl derivative of chloroacetamide. One of the method reported for its synthesis is by the reaction of 2-chloracetamide with formaldehyde. It has been reported to be a formaldehyde releaser and an infrequent sensitizer to formaldehyde contact allergy. Influence of short and prolonged exposure of 2-chloro-N-(hydroxymethyl)acetamide (as formaldehyde donor/releaser) on lymph node responses has been investigated. It has high biocide action and is utilized as preservative.
| Pubchem Sid | 504753846 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504753846 |
| Canonical Smiles | C(C(=O)NCO)Cl |
| IUPAC Name | 2-chloro-N-(hydroxymethyl)acetamide |
| InChIKey | TXNSZCSYBXHETP-UHFFFAOYSA-N |
| INCHI | 1S/C3H6ClNO2/c4-1-3(7)5-2-6/h6H,1-2H2,(H,5,7) |
| Isomeric SMILES | C(C(=O)NCO)Cl |
| WGK Germany | 3 |
| RTECS | AB5733000 |
| Molecular Weight | 123.54 |
| Reaxy-Rn | 1811765 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1811765&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Class | Carboxylic acids and derivatives |
| Subclass | Carboxylic acid derivatives |
| Intermediate Tree Nodes | Carboxylic acid amides |
| Direct Parent | Chloroacetamides |
| Alternative Parents | Secondary carboxylic acid amides Alkanolamines Organopnictogen compounds Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds Alkyl chlorides |
| Molecular Framework | Aliphatic acyclic compounds |
| Substituents | Chloroacetamide - Secondary carboxylic acid amide - Alkanolamine - Organic nitrogen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Carbonyl group - Alkyl halide - Alkyl chloride - Aliphatic acyclic compound |
| Description | This compound belongs to the class of organic compounds known as chloroacetamides. These are organic compounds with the general formula RNHC(=O)CH2Cl, where R= organyl group. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 J2227182 | Certificate of Analysis | Aug 11, 2025 | C169257 |
| J2227183 | Certificate of Analysis | Aug 11, 2025 | C169257 |
| J2227232 | Certificate of Analysis | Aug 11, 2025 | C169257 |
| J2227240 | Certificate of Analysis | Aug 11, 2025 | C169257 |
| J2227241 | Certificate of Analysis | Aug 11, 2025 | C169257 |
| Solubility | Very soluble in water. Poorly soluble in aliphatic hydrocarbons. |
|---|---|
| Sensitivity | Moisture sensitive. |
| Melt Point(°C) | 100-105 °C |
| Molecular Weight | 123.540 g/mol |
| XLogP3 | -0.400 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 2 |
| Exact Mass | 123.009 Da |
| Monoisotopic Mass | 123.009 Da |
| Topological Polar Surface Area | 49.300 Ų |
| Heavy Atom Count | 7 |
| Formal Charge | 0 |
| Complexity | 66.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
