Allo-aca - ≥99% , CAS No.A658698

CAS: A658698 Cat. No.: A658698 Formula: C₄₈H₇₅N₁₃O₁₅ Molecular Weight: 1074.19

GRADE & PURITY ≥99%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models.

Appearance:Solid

In Vitro:Allo-aca inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca inhibits leptin-induced proliferation of MCF-7 cells with an IC 50 of 200 pM. Allo-aca at 250 nmol/L reduces VEGF-dependent leptin mRNA expression

In Vivo:In an MDA-MB-231 orthotopic mouse xenograft model, Allo-aca administered subcutaneously significantly extends the average survival time from 15.4 days (untreated controls) to 24 and 28.1 days at 0.1 and mg/kg/day doses, respectively. MCE has not ind

Biological Activity:Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models .

Specifications

Specifications & Purity

≥99%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Purity

≥99%

Names and Identifiers

Molecular Weight

1074.19

Chemical and Physical Properties

• Solubility: H2O : 50 mg/mL (46.55 mM; Need ultrasonic)