Apamin TFA - ≥96% , CAS No.A659185

CAS: A659185 Cat. No.: A659185 Formula: C₈₁H₁₃₂F₃N₃₁O₂₆S₄ Molecular Weight: 2141.36

GRADE & PURITY ≥96%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca 2+ -activated K + (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity.

Appearance:Solid

IC50& Target:K + channel

In Vitro:Apamin (0.5-2 µg/mL; 24 hours; HSC-T6 cells) treatment markedly reduces the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Apamin treatment abrogats the activation of p-Smad2/3 and Smad4 induced by TGF-β1. MCE has not independently confirmed

In Vivo:Apamin (0.1mg/kg; intraperitoneal injection; twice a week; for 4 weeks; C57BL/6 male mice) treatment results in decreased liver injury and proinflammatory cytokine levels. Apamin suppresses the deposition of collagen, proliferation of BECs and expression

Biological Activity:Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca 2+ -activated K + (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity.

Specifications

Specifications & Purity

≥96%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥96%

Names and Identifiers

Molecular Weight

2141.36

Chemical and Physical Properties

• Solubility: H2O : 50 mg/mL (23.35 mM; Need ultrasonic)