APETx2 TFA, CAS No.713544-47-9(free base)

CAS: 713544-47-9(free base) Cat. No.: A274913 Molecular Weight: 4675.02

GRADE & PURITY Moligand™, ≥95%

Overview

APETx2 TFA, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC50 of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain.

Specifications

Product Name

APETx2 TFA, CAS No.713544-47-9(free base)

Grade

Moligand™

Specifications & Purity

Moligand™, ≥95%

Biochemical and Physiological Mechanisms

Selective, reversible ASIC3 channel blocker (IC 50 = 63 nM) . Inhibits heteromeric ASIC2b and ASIC3 currents (IC 50 = 117 nM) and Na V 1.8 channels (IC 50 = 2.6 μM). Shows analgesic effects in vivo .

Sequence

H-Gly-DL-xiThr-DL-Ala-DL-Cys(1)-DL-Ser-DL-Cys(2)-Gly-DL-Asn-DL-Ser-DL-Lys-Gly-DL-xiIle-DL-Tyr-DL-Trp-DL-Phe-DL-Tyr-DL-Arg-DL-Pro-DL-Ser-DL-Cys(3)-DL-Pro-DL-xiThr-DL-Asp-DL-Arg-Gly-DL-Tyr-DL-xiThr-Gly-DL-Ser-DL-Cys(2)-DL-Arg-DL-Tyr-DL-Phe-DL-Leu-Gly-DL-xiThr-DL-Cys(1)-DL-Cys(3)-DL-xiThr-DL-Pro-DL-Ala-DL-Asp-OH

Action Type

INHIBITOR

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

CAS

713544-47-9(free base)

Molecule Type

Peptide

Storage and Shipping

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads