Azithromycin (CP-62993) - Moligand™, 10mM in DMSO , Bacterial 70S ribosome inhibitor, CAS No.83905-01-5, Bacterial 70S ribosome inhibitor

CAS: 83905-01-5 Cat. No.: A409086 Formula: C₃₈H₇₂N₂O₁₂ Molecular Weight: 748.98 EC Number: 617-500-5

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

XZ-450 | (2R,​3S,​4R,​5R,​8R,​10R,​11R,​12S,​13S,​14R)​-13-​[(2,​6-​dideoxy-​3-​C-​methyl-​3-​O-​methyl-​α-​L-​ribo-​hexopyranosyl)​oxy]​-​2-​ethyl-​3,​4,​10-​trihydroxy-​3,​5,​6,​8,​10,​12,​14-​heptamethyl-​11-​[[3,​4,​6-​trideoxy-​3-​(dimethylamino)​-​β

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.
In vitro

Azithromycin reduces about 40% of IL-8 mRNA and protein expression in cystic fibrosis (CF) cells reaching the levels of non-CF cells. Azithromycin results in 50% and 70% reduction of NF-kappaB and AP-1 DNA binding, respectively, leading to levels of non-CF cells. Azithromycin significantly enhances the intensity of a co-stimulatory molecule, CD80, on DCs but not CD86 and CD40 in dendritic cells (DCs). Azithromycin significantly increases the production of IL-10 and Clarithromycin (CAM) significantly inhibits the production of IL-6 by DCs. Azithromycin increases IL-10 and CAM decreases IL-2 productions significantly, when naive T cells derived from spleen are co-cultured with DCs treated in advance with LPS and these macrolides. Azithromycin selectively inhibits fluid-phase endocytosis of horseradish peroxidase and lucifer yellow in J774 mouse macrophages. Azithromycin delays sequestration of receptor-bound transferrin and peroxidase-anti-peroxidase immune complexes into cell-surface endocytic pits and vesicles. Azithromycin down-regulates cell surface transferrin receptors, but not Fc gamma receptors, by causing a major delay in the accessibility of internalized transferrin receptors to the recycling route, without slowing down subsequent efflux, resulting in redistribution of the surface pool to an intracellular pool. Azithromycin inserts into the DOPC lipid bilayer, so as to decrease its cohesion and to facilitate the merging of DPPC into the DOPC fluid matrix.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:

Specifications

Synonyms

XZ-450 | (2R,​3S,​4R,​5R,​8R,​10R,​11R,​12S,​13S,​14R)​-13-​[(2,​6-​dideoxy-​3-​C-​methyl-​3-​O-​methyl-​α-​L-​ribo-​hexopyranosyl)​oxy]​-​2-​ethyl-​3,​4,​10-​trihydroxy-​3,​5,​6,​8,​10,​12,​14-​heptamethyl-​11-​[[3,​4,​6-​trideoxy-​3-​(dimethylamino)​-​β

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST, INHIBITOR

Mechanism of action

Bacterial 70S ribosome inhibitor

Product Properties

alogp

4

Names and Identifiers

Isomeric SMILES

CC[C@@H]1[C@@]([C@@H]([C@H](N(C[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O

WGK Germany

2

RTECS

RN6960000

Molecular Weight

748.98

Reaxy-Rn

5387583

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5387583&ln=

Associated Targets(Human)

MLNR Tchem Motilin receptor (1 Activities)

Discover Target: MLNR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 25 mg/mL (198.23 mM)