Bemfivastatin - ≥99% , CAS No.805241-79-6

CAS: 805241-79-6 Cat. No.: B1440727 Formula: C₃₄H₃₇FN₂O₆ Molecular Weight: 588.67

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Overview

Bemfivastatin (PPD 10558) is an orally active, HMG-CoA Reductase (HMGCR) inhibitor , also known as Statin. Bemfivastatin enhances the activity of liver extraction. Bemfivastatin exhibits little developmental toxicity effects in pregnant rats and rabbits via daily oral doses during organogenesis period. The no observed adverse effect level (NOAEL) are ≥320 mg/kg/day for rats developmental toxicity, 12.5 mg/kg/day for rabbits maternal toxicity, and 25 mg/kg/day for rabbits developmental toxicity, respectively. Bemfivastatin can be used for research on Statin-related hypercholesterolemic myalgia with inability to tolerate statins.

Specifications

Specifications & Purity

≥99%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

Molecular Weight

588.67

Application Protocols

No validated application protocols are provided for this SKU in the Product Data.

General starting points (non-item-specific)

• Preparation of 10 mM DMSO stock: Weigh the required amount quickly in low light, add anhydrous DMSO to volume, vortex and briefly sonicate if needed. Aliquot and store per guidance below.
• Cell-based assays: Dilute from DMSO stock into pre-warmed media, targeting ≤0.1–0.5% final DMSO. Include vehicle controls at matched solvent content. Assess compound precipitation microscopically if possible.
• Biochemical assays: Prepare serial dilutions in assay buffer containing 0.01% Tween 20/80 if nonspecific adsorption or aggregation is suspected; include detergent controls.
• Analytical QC on receipt: Run LC–MS to confirm expected mass and HPLC purity using the CoA as reference.

Please consult the CoA/Spec Sheet for any item-specific directions once available.

Biological Roles

No target, pathway, or mechanism of action information is provided in the Product Data for this SKU. Therefore, item-specific biological roles cannot be assigned here.

General research context (non-item-specific)

• Small molecules from compound libraries are commonly used as: (a) tool compounds to probe cellular pathways; (b) hits/leads in phenotypic or target-based screens; and (c) analytical reference materials in bioanalytical method development.
• Typical experimental sequence: initial activity screening; secondary assays for potency/selectivity; orthogonal biophysical binding assays (e.g., DSF, SPR, thermal shift); and cellular target engagement where applicable.
• ADME profiling: If downstream use requires, evaluate solubility, permeability (PAMPA/Caco-2), microsomal stability, and protein binding; these properties are compound-specific and require empirical measurement.

Important

• This product is for research use only. No claims are made regarding therapeutic value or clinical performance.
• For any biology-facing experiment, obtain the structure and purity data from the CoA/Spec Sheet to enable mechanistic interpretation and appropriate controls.

Buffer Applications

This item is a discrete small organic molecule, not a buffering agent. It is not typically used to prepare buffer systems.

Practical notes for using in buffered assays (general)

• Stock solutions: Prepare a concentrated stock in DMSO or ethanol, then dilute into the desired buffer (e.g., PBS, HEPES, Tris) with vigorous mixing to achieve the target final concentration and ≤0.1–1% v/v organic cosolvent.
• Precipitation control: Add stock slowly to the buffer while vortexing. If turbidity forms, increase temperature slightly (to ambient–37 °C), reduce final concentration, or incorporate minimal surfactant (e.g., 0.01% Tween 80) as compatible with the assay.
• Adsorption: Hydrophobic compounds can adsorb to plastics; prefer low-bind polypropylene or glass vials and assay plates designed for organic additives.

Buffer recipes and pH ranges are not applicable to this item directly; select your buffer based on the biological system under study.

Green Alternatives

Because this item is a discrete screening compound rather than a solvent or common reagent, “green alternatives” pertain primarily to solvent and process choices used with the compound rather than to the compound itself.

Greener handling strategies (general guidance)

• Prefer greener stock solvents when compatible: ethanol or 2-propanol can sometimes substitute for DMSO/DMF for moderate-solubility compounds, reducing worker exposure and environmental impact.
• Use high–solids, low–volume approaches: Prepare high-concentration stocks to minimize solvent volume carried into assays; apply acoustic or pin-tool dispensing to reduce waste.
• Explore aqueous enabling excipients: hydroxypropyl-β-cyclodextrin (HP-β-CD) or minimal % polysorbates can improve apparent solubility, lowering organic solvent demand.

Illustrative comparison (non-item-specific)

• DMSO: excellent solvency; not particularly green; high boiling point complicates removal.
• Ethanol: renewable, low toxicity, easy removal; may offer lower solubility for highly lipophilic compounds.
• 2-MeTHF/EtOAc (for work-up/crystallization): more sustainable than chlorinated solvents, with good performance for many organics.

Verification

• Confirm chemical compatibility (no transesterification, no base/acid lability) before adopting alternative solvents. Protect from light throughout, per Product Data.

Pharmaceutical Uses

No pharmacopeial status, excipient role, or manufacturing grade is provided for this SKU. The product is designated for research use only.

General, non-therapeutic context (non-item-specific)

• Tool/analytical material: May serve as a research tool compound or analytical reference during method development and validation in non-GMP settings once identity/purity are verified from the CoA.
• Preformulation studies: For medicinal chemistry programs, small quantities may be used to explore solubility enhancement strategies (salt formation if ionizable, co-crystals, amorphous dispersions) strictly in a research context.

Important limitations

• Not for human or veterinary use; not intended for formulation into drug products.
• No claims are made regarding therapeutic indications, efficacy, or safety.

For any application approaching regulated use, obtain detailed specifications, impurity profiles, and stability data under ICH conditions. None of these are specified for this item in the current Product Data.

Physical Properties

Only general guidance can be provided; item-specific physicochemical values have not been supplied.

Item-specific (from Product Data)

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.

Commonly requested properties (this item)

• Melting/boiling point: Not specified for this item; refer to CoA/Spec Sheet.
• Density/refractive index: Not specified for this item; refer to CoA/Spec Sheet.
• Solubility (water/organic): Not specified for this item; refer to CoA/Spec Sheet.
• LogP/logD, pKa: Not specified for this item; refer to CoA/Spec Sheet.

General laboratory guidance (literature/practice, non-item-specific)

• Many drug-like small molecules are poorly water-soluble and dissolve readily in polar aprotic solvents (DMSO, DMF) and moderately in alcohols (MeOH, EtOH). A typical approach is to prepare a 10–50 mM DMSO stock, then dilute into assay buffer with final DMSO ≤0.1–1% v/v, as tolerated by the biology.
• If crystallinity or polymorphism affects dissolution, brief warming (≤40 °C) and sonication can assist; avoid prolonged heating or light exposure given the product’s storage note to protect from light.

For definitive property values for Bemfivastatin (CAS 805241-79-6), consult the CoA/Spec Sheet or request analytical characterization data.

Quality and Grades

Item-specific quality attributes were not provided in the Product Data.

• Grade/purity: Not specified for this item; refer to CoA/Spec Sheet.
• Stabilizers/antioxidants: Not specified for this item; refer to CoA/Spec Sheet.

How to interpret grades (general guidance)

• Research grade chemicals are suitable for discovery biology/chemistry workflows and routine analytical development; they are not certified for GMP use.
• If the item is offered in “HPLC” or “LC–MS” grade variants, that typically implies low UV background/particulate and tight control of non-volatile residue for chromatographic applications.
• For screening libraries, batch-to-batch consistency is commonly supported by NMR/LC–MS identity and purity checks (e.g., ≥95% by HPLC), though the exact threshold must be confirmed on the CoA for this SKU (B1440727).

Recommended quality verification on receipt

• Request and review CoA: identity (1H NMR, MS), purity (HPLC/UPLC with chromatogram), water content (KF) if moisture-sensitive, and residual solvent profile as relevant.
• For bioassay use, consider independent spot-check by LC–MS to confirm mass and purity in your lab matrix.

Reaction and Applications

This product is listed under small molecules/compound libraries and is primarily intended for biochemical/chemical biology research rather than as a general-purpose reagent. No manufacturer application notes or mechanistic annotations were provided for this SKU.

Research applications (general, non-item-specific)

• Chemical biology: Use as a test article in biochemical/biophysical assays, phenotypic screens, or target-engagement studies. Typical workflows include concentration–response profiling, time-dependence, and selectivity panels.
• Reference material: Employ as a reference standard for analytical method development (HPLC/UPLC retention, LC–MS/MS MRM transition development) once structure/mass data are available from the CoA.
• Formulation screening: Evaluate solubilization strategies for in vitro assays (co-solvents, cyclodextrins, lipidic vehicles) while monitoring stability under light due to the storage note.

Analytical considerations

• Stability-indicating methods: Develop LC–UV/LC–MS methods to track degradation pathways (hydrolysis/oxidation/isomerization as applicable). Conduct stress tests at pH 2/7/10 and light exposure to bracket handling conditions.

Note: Specific reaction chemistry (e.g., as a reagent or building block) is not documented for this item. If you intend to derivatize or immobilize it, obtain the structure and functional group information from the CoA/Spec Sheet first.

Reaction Conditions

No item-specific reaction conditions are applicable because this product is not supplied as a reagent for a defined transformation. However, practical conditions for solution preparation and analytical handling are provided below.

Solution preparation (general)

• Prepare a concentrated stock in dry DMSO (10–50 mM typical). Mix thoroughly; gentle warming (≤40 °C) and brief sonication can aid dissolution. Protect from light.
• For aqueous assays, dilute the DMSO stock into buffer with rapid mixing to a final DMSO content compatible with your system (commonly 0.1–1% v/v). Inspect for precipitation.

Stability assessments (general)

• Photostability: Given the storage instruction to protect from light, evaluate light sensitivity by exposing aliquots to ambient light and monitoring by LC–UV/LC–MS.
• pH stability: Incubate aliquots in buffers spanning pH 2–10 at ambient temperature and monitor degradation over 24–72 h to define handling windows.

Chromatography (general)

• Reverse-phase HPLC: Start with C18, 5 µm, 150 × 4.6 mm; gradient 5–95% acetonitrile in water (0.1% formic acid) over 15–20 min; UV 210–280 nm. Adjust based on actual chromophore once known.

All numerical values above are general literature practices and not specifications for this item.

Safety and Handling

Safety information specific to this catalog item is incomplete in the Product Data. Always consult the SDS for authoritative guidance before use.

Item-specific hazard fields

• Signal word: Not specified for this item; refer to SDS.
• H-statements/GHS classification/pictograms: Not specified for this item; refer to SDS.

General laboratory precautions (good practice)

• Personal protective equipment: lab coat, safety glasses, and appropriate chemical-resistant gloves (e.g., nitrile). Work in a fume hood to minimize inhalation exposure.
• Storage: Store at 2–8 °C, protected from light, desiccated (per Product Data). Shipments are on wet ice.
• Incompatibilities: Without structural data, avoid strong oxidizers/reductants and strong acids/bases until compatibility is known. Keep away from moisture if hydrolysis is a risk for the scaffold.
• First aid overview: In case of skin/eye contact, rinse with water for at least 15 minutes; remove contaminated clothing. If inhaled, move to fresh air. If ingested, rinse mouth; do not induce vomiting; seek medical attention. Defer to SDS for specifics.
• Spill response: Absorb with inert material, collect in appropriate waste container. Avoid dust/aerosol generation.

Waste disposal

• Dispose of in accordance with institutional and local regulations for non-volatile organic research chemicals. Segregate halogenated vs non-halogenated solvent wastes as applicable.

Note: This material is for research use only (not for human or veterinary use).

Solvent Selection

No item-specific solubility data are provided. The guidance below reflects common practice for small, hydrophobic research compounds; verify experimentally at small scale.

• Likely stock solvent choices (general): DMSO is typically preferred for high-concentration stocks (10–50 mM). DMF, NMP, or ethanol can be alternatives when DMSO is undesirable. For preparative work-up or crystallization, EtOAc, MeOH/EtOH, acetonitrile, or MTBE may be explored.
• Aqueous use: Prepare a DMSO or ethanol concentrate and dilute into buffered media with vigorous mixing to a final co-solvent level tolerated by your assay (commonly 0.1–1% v/v). Adding 0.01–0.05% nonionic surfactant (e.g., Tween 80) can improve dispersion for very hydrophobic entities.
• pH adjustment: If the compound bears ionizable groups (unknown here), pH can dramatically alter solubility. Screen pH 2–10 in the presence of co-solvent.

Quick comparison (general, non-item-specific)

• DMSO: maximal solvating power; high boiling point; miscible with water. Potential biological interference at >1%.
• Ethanol: greener, volatile; miscible with water; lower solvating power than DMSO.
• DMF/NMP: strong solvents; consider toxicity and removal challenges.

Note: Protect from light during solution handling per Product Data. Filter stock solutions (0.22 µm PTFE) to remove particulates if needed.

Storage and Reconstitution

Item-specific storage conditions are provided; reconstitution details are general best practices for small molecules.

Storage (from Product Data)

• Store at 2–8 °C.
• Protect from light.
• Keep desiccated.
• Shipped on wet ice.

Reconstitution and handling (general)

• Work quickly under low light. Allow the container to equilibrate to room temperature in a desiccator before opening to avoid moisture condensation.
• Prepare concentrated stocks in anhydrous DMSO or ethanol. Typical screening stock concentrations: 10–50 mM (verify solubility experimentally). Filter through 0.22 µm PTFE if particulates persist.
• Aliquot into amber, low-bind microtubes or vials to minimize headspace and adsorption. Flush with inert gas if oxidation sensitivity is suspected.
• Storage of solutions: Store DMSO stocks at −20 °C (preferred) or 2–8 °C for short term, protected from light. Avoid repeated freeze–thaw; use single-use aliquots. Monitor integrity by periodic LC–MS/HPLC.

Notes

• Appearance, purity, and exact solubility are not specified; consult the CoA/Spec Sheet for item-specific guidance.
• For aqueous working solutions, prepare fresh on the day of use unless stability is established under your assay conditions.

Structure and Identity

A small-molecule research compound supplied as part of a screening/compound library entry. Item-specific structural identifiers have not been provided in the Product Data.

• Chemical name: Bemfivastatin (catalog designation)
• CAS: 805241-79-6
• Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• InChIKey: Not specified for this item; refer to CoA/Spec Sheet.

Structural features

• Specific functional groups, stereochemistry, and ring systems are not available in the provided data. No assumptions are made beyond the catalog name.
• If structural confirmation is required for your workflow (e.g., docking, QSAR, metabolite prediction), request the CoA/Spec Sheet or analytical data (NMR, LC–MS) from Aladdin Scientific.

2D depiction in words

• Not possible to describe without the structure. For cheminformatics import, SMILES or InChI are needed (not supplied here).

Synthetic Utility

This catalog entry represents a finished small molecule intended for screening or as a tool compound. Without structural information, specific synthetic transformations involving this molecule cannot be proposed.

Potential uses in synthetic/analytical workflows (general)

• Analytical standard: Once structural and mass data are available from the CoA, the compound can be used to develop and calibrate LC–MS/MS assays (selection of precursor/product ions, collision energies) and HPLC purity methods.
• Derivatization/immobilization: If the molecule bears suitable handles (e.g., carboxyl, amine, hydroxyl; unknown here), it could be derivatized for affinity matrices or probe development. Such work requires confirmed functional group information.
• Stability studies: Conduct forced-degradation mapping (acid/base, oxidative, photolytic per light-protection note) to define stability-indicating methods prior to broader deployment in screening or storage as a working standard.

Recommendation

• Request structure and spectral data. If synthetic manipulation is desired, perform small-scale reactivity scouting under inert atmosphere and controlled pH, monitoring by LC–MS to avoid over-transformation of unknown labile motifs.

Target Specificity

Target, epitope, or selectivity information has not been provided for this item.

• Target/biomolecule class: Not specified for this item; refer to CoA/Spec Sheet or associated literature if available.
• Species reactivity/clone/isotype: Not applicable (this product is a small molecule, not an antibody).

For projects requiring defined target engagement, pair this item with orthogonal assays (biochemical and biophysical) and obtain structural data to contextualize activity.

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 805241-79-6, the molecular formula is C34H37FN2O6, and the molecular weight is 588.67 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.