Benserazide HCl - 10mM in DMSO , CAS No.14919-77-8

CAS: 14919-77-8 Cat. No.: B408796 Molecular Weight: 293.7 EC Number: 238-991-9

GRADE & PURITY 10mM in DMSO

Synonyms

Ro-4-4602 | N'-(2,3,4-trihydroxybenzyl)-2-amino-3-hydroxypropanehydrazide, hydrochloride(1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Benserazide HCl Benserazide HCl (Ro-4-4602) is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.
In vitro

In vivo

Cell Data

cell lines：U937, KG-1, KBM-3B, ML-1, HL-60, and MEG-01

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Ro-4-4602 | N'-(2, 3, 4-trihydroxybenzyl)-2-amino-3-hydroxypropanehydrazide, hydrochloride(1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Benserazide HCl (Ro-4-4602) is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C1=CC(=C(C(=C1CNNC(=O)C(CO)N)O)O)O.Cl
• WGK Germany: 2
• RTECS: VT9632300
• Alternate CAS: 322-35-0
• Molecular Weight: 293.7
• Reaxy-Rn: 6494463
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6494463&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro Ethanol: mg/mL
• Melt Point(°C): 180 °C(dec.)

References

1. Yizhen Guo, Ding Huang, Yan Zhou, Maoxin Ran, Shaolin Zhang, Kin Yip Tam.  (2025)  Targeting Metabolic Vulnerabilities Reveals Hexokinase 2 as a Key Mediator of Resistance to Osimertinib in Non-Small Cell Lung Cancer Models.  ACS Pharmacology & Translational Science,      [PMID:40810158] [10.1021/acsptsci.5c00235]