Biliatresone - ≥99% , CAS No.1801433-90-8
In stock
SKU
B650631
Flavonoids Isoflavones
Biliatresone is a natural toxin isolated from Dysphania glomulifera and D. littoralis. Biliatresone, a 1,2-diaryl-2-propenone class of isoflavonoid, produces extrahepatic biliary atresia in a zebrafish model.
In Vitro
Biliatresone has a reduction in primary cilia and a dose-dependent decrease in visible microtubules, suggesting that Biliatresone decreases microtubule stability in primary neonatal mouse extrahepatic cholangiocytes. Biliatresone (2 µg/ml; for 24 hours) shows disruption of the spheroid lumen and abnormal cholangiocyte polarity in mouse cholangiocyte. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Biliatresone exhibits toxicity at doses of 0.065-1.0 μg/mL with a marked reduction and the lethal dose of Biliatresone in a zebrafish assay is 1 μg/mL . Larvae treated at 5 dpf with low doses of biliatresone [0.0625 µg/ml (0.2 µM) and 0.125 µg/ml (0.4 µM)] shows only subtle gallbladder defects, whereas larvae treated with higher doses has pronounced morphological defects of the gallbladder and extrahepatic ducts . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Viscous liquid
More Information
| CAS | 1801433-90-8 |
|---|---|
| Specifications & Purity | ≥99% |
| Storage | Argon charged,Store at -80°C |
| Shipped In | Dry ice packs + Cold packs |
| Product Description | Biliatresone is a natural toxin isolated from Dysphania glomulifera and D. littoralis. Biliatresone, a 1,2-diaryl-2-propenone class of isoflavonoid, produces extrahepatic biliary atresia in a zebrafish model. In Vitro Biliatresone has a reduction in primary cilia and a dose-dependent decrease in visible microtubules, suggesting that Biliatresone decreases microtubule stability in primary neonatal mouse extrahepatic cholangiocytes. Biliatresone (2 µg/ml; for 24 hours) shows disruption of the spheroid lumen and abnormal cholangiocyte polarity in mouse cholangiocyte. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Biliatresone exhibits toxicity at doses of 0.065-1.0 μg/mL with a marked reduction and the lethal dose of Biliatresone in a zebrafish assay is 1 μg/mL . Larvae treated at 5 dpf with low doses of biliatresone [0.0625 µg/ml (0.2 µM) and 0.125 µg/ml (0.4 µM)] shows only subtle gallbladder defects, whereas larvae treated with higher doses has pronounced morphological defects of the gallbladder and extrahepatic ducts . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Viscous liquid |
| Solubility | DMSO : 50 mg/mL (152.29 mM; Need ultrasonic) H2O : 12.5 mg/mL (38.07 mM; ultrasonic and warming and heat to 60°C) |
| PubChem CID | 124079379 |
| Molecular Formula | C18H16O6 |
Reviews
Customer Reviews
Remind me later