bio-THZ1 - ≥98% , CAS No.1604811-14-4

CAS: 1604811-14-4 Cat. No.: B647017 Formula: C₅₂H₆₅ClN₁₂O₈S Molecular Weight: 1053.67 PubChem CID: 139035075

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7 . THZ1 is a selective and potent covalent CDK7 inhibitor with an IC 50 of 3.2 nM

Form:Solid

IC50& Target:CDK7

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7 . THZ1 is a selective and potent covalent CDK7 inhibitor with an IC 50 of 3.2 nM.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CN(CCCNC(=O)NCCOCCOCCOCCNC(=O)CCCCC1C2C(CS1)NC(=O)N2)CC=CC(=O)NC3=CC=C(C=C3)C(=O)NC4=CC=CC(=C4)NC5=NC=C(C(=N5)C6=CNC7=CC=CC=C76)Cl
• IUPAC Name: 4-[[(E)-4-[3-[2-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]propyl-methylamino]but-2-enoyl]amino]-N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide
• InChIKey: ARPCJVVFIKPHFA-SFDVBDGFSA-N
• INCHI: 1S/C52H65ClN12O8S/c1-65(24-8-20-55-51(69)56-22-26-72-28-30-73-29-27-71-25-21-54-45(66)14-5-4-13-44-48-43(34-74-44)62-52(70)64-48)23-7-15-46(67)59-36-18-16-35(17-19-36)49(68)60-37-9-6-10-38(31-37)61-50-58-33-41(53)47(63-50)40-32-57-42-12-3-2-11-39(40)42/h2-3,6-7,9-12,15-19,31-33,43-44,48,57H,4-5,8,13-14,20-30,34H2,1H3,(H,54,66)(H,59,67)(H,60,68)(H2,55,56,69)(H,58,61,63)(H2,62,64,70)/b15-7+/t43-,44-,48-/m0/s1
• PubChem CID: 139035075
• Molecular Weight: 1053.67

Chemical and Physical Properties

• Solubility: DMSO : 120 mg/mL (113.89 mM; Need ultrasonic)

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1604811-14-4, the molecular formula is C52H65ClN12O8S, and the molecular weight is 1053.67 g/mol. InChIKey ARPCJVVFIKPHFA-SFDVBDGFSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.