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CDK/HDAC-IN-2 is a potent HDAC/CDK dual inhibitor with IC 50 of 6.4, 0.25, 45, >1000, 8.63, 0.30, >1000 nM for HDAC1 , HDAC2 , HDAC3 , HDAC6 ,8, CDK1 , CDK2 , CDK4 ,6,7, respectively. CDK/HDAC-IN-2 shows excellent antiproliferative activities. CDK/HDAC-IN-2 induces apoptosis and cell cycle arrest at G2/M phase. CDK/HDAC-IN-2 shows potent antitumor efficacy.
| CAS | 2580938-58-3 |
|---|---|
| Storage | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | CDK/HDAC-IN-2 is a potent HDAC/CDK dual inhibitor with IC 50 of 6.4, 0.25, 45, >1000, 8.63, 0.30, >1000 nM for HDAC1 , HDAC2 , HDAC3 , HDAC6 ,8, CDK1 , CDK2 , CDK4 ,6,7, respectively. CDK/HDAC-IN-2 shows excellent antiproliferative activities. CDK/HDAC-IN-2 induces apoptosis and cell cycle arrest at G2/M phase. CDK/HDAC-IN-2 shows potent antitumor efficacy. |