Cefdinir - Moligand™, 10mM in DMSO , CAS No.91832-40-5

CAS: 91832-40-5 Cat. No.: C407774 Molecular Weight: 395.41 EC Number: 643-088-1

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

FK 482, PD 134393, CI-983 | (6R,​7R)​-7-​[[(2Z)​-​2-​(2-​amino-​4-​thiazolyl)​-​2-​(hydroxyimino)​acetyl]​amino]​-​3-​ethenyl-​8-​oxo-5-​thia-​1-​azabicyclo[4.2.0]​oct-​2-​ene-​2-​carboxylic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Cefdinir (FK 482, PD 134393, CI-983) is an oral cephalosporin antibiotic, used to treat bacterial infections in many different parts of the body.
In vitro

Cefdinir, a new oral 2-amino-5-thiazolyl cephalosporin, inhibits the luminol-amplified chemiluminescence (LACL) response of human neutrophils stimulated by PMA but not opsonized zymosan, in a concentration-dependent but not time-dependent manner. Cefdinir inhibits LACL generation in cell-free systems consisting of H₂O₂, NaI, and either horseradish peroxidase or amyeloperoxidase-containing neutrophil extract. Cefdinir impairs LACL response induced by the calcium ionophore A23187 and FMLP, and this impairment is increased in cytochalasin B-treated neutrophils. Cefdinir directly inhibits the activity of myeloperoxidase-containing neutrophil extract released into the extracellular medium during neutrophil stimulation by soluble mediators, but has no effect on that released into the phagolysosome during phagocytosis. Cefdinir demonstrates excellent activity against a wide range of gram-positive and gram-negative bacteria. Cefdinir is resistant to a broad variety of β-lactamases and exhibits a β-lactam stability profile generally better than those observed with cefaclor and cefuroxime. Cefdinir elimination is primarily mediated by the kidney. Cefdinir interacts with the dipeptide transporters PEPT1 and PEPT2. Cefdinir tubular reabsorption is substantial, that Cefdinir tubular secretion is inhibitable by probenecid, and that this secretion is probably mediated by the renal organic anion secretory pathway.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

FK 482, PD 134393, CI-983 | (6R, ​7R)​-7-​[[(2Z)​-​2-​(2-​amino-​4-​thiazolyl)​-​2-​(hydroxyimino)​acetyl]​amino]​-​3-​ethenyl-​8-​oxo-5-​thia-​1-​azabicyclo[4.2.0]​oct-​2-​ene-​2-​carboxylic acid

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Cefdinir (FK 482, PD 134393, CI-983) is an oral cephalosporin antibiotic, used to treat bacterial infections in many different parts of the body.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: C=CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\O)/C3=CSC(=N3)N)SC1)C(=O)O
• Molecular Weight: 395.41
• Reaxy-Rn: 37811625
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37811625&ln=

Chemical and Physical Properties

• Specific Rotation[α]: -65° (C=1,0.1mol/L pH7.0 phoshate Buffer)
• Melt Point(°C): 190 °C(dec.)

References

1. Guanxing Chen, Haohuai He, Lu Zhao, Qiujie Lv, Calvin Yu-Chian Chen.  (2023)  GINCM-DTA: A graph isomorphic network with protein contact map representation for potential use against COVID-19 and Omicron subvariants BQ.1, BQ.1.1, XBB.1.5, XBB.1.16.  EXPERT SYSTEMS WITH APPLICATIONS,      [PMID:] [10.1016/j.eswa.2023.121274]