Ceftiofur HCl - 10mM in DMSO , CAS No.103980-44-5

CAS: 103980-44-5 Cat. No.: C408669 Formula: C₁₉H₁₇N₅O₇S₃.HCl Molecular Weight: 560.02 EC Number: 600-507-2

GRADE & PURITY 10mM in DMSO

Synonyms

U-67279A | (6R,​7R)​-7-​[[(2Z)​-​2-​(2-​amino-​4-​thiazolyl)​-​2-​(methoxyimino)​acetyl]​amino]​-​3-​[[(2-​furanylcarbonyl)​thio]​methyl]​-​8-​oxo-5-​thia-​1-​azabicyclo[4.2.0]​oct-​2-​ene-​2-​carboxylic acid​, hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Ceftiofur HCl (U-67279A) is a cephalosporinantibiotic, used to treat both Gram-positive and Gram-negative bacteria infection.
In vitro

Ceftiofur can downregulate tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), but did not affect interleukin-10 (IL-10) production. Ceftiofur significantly inhibits extracellular signal-regulated kinase (ERK), p38, and c-jun NH(2)-terminal kinase (JNK) phosphorylation protein expression in RAW 264.7 cells. Ceftiofur also inhibits p65-NF-kappaB translocation into the nucleus in RAW 264.7 cells.

In vivo

Ceftiofur treatment is associated with a significant decrease in rectal temperature and diarrhea in neonatal calves. Ceftiofur results in a significant decrease in fecal shedding of Salmonella organisms in neonatal calves. Ceftiofur hydrochloride (intrauterine (i.u.)) reduces the prevalence of positive uterineculture in cows with clinical endometritis (29.0 vs. 51.4%) and reduces the overall prevalence of Arcanobacterium pyogenes (1.0 vs. 7.6%) at 51 d in milk (DIM) . Ceftiofur hydrochloride reduces the prevalence of uterine infection in cows with clinical endometritis, and the prevalence of A. pyogenes, but does not affect the prevalence of subclinical endometritis or fertility of dairy cows already receiving PGF(2alpha). Ceftiofur hydrochloride (i.m. injection) results in C(max) of 11.8 mg/mL at 1-4 hours after injection, the mean area under the curve (AUC) of 216 m g x h/mL in pigs. Ceftiofur hydrochloride （2.2 mg of CE/kg, SC or IM, once daily for 5 days） is efficacious for treatment of acute postpartum metritis (APM) in dairy cows.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥95%

Specifications

Synonyms

U-67279A | (6R,​7R)​-7-​[[(2Z)​-​2-​(2-​amino-​4-​thiazolyl)​-​2-​(methoxyimino)​acetyl]​amino]​-​3-​[[(2-​furanylcarbonyl)​thio]​methyl]​-​8-​oxo-5-​thia-​1-​azabicyclo[4.2.0]​oct-​2-​ene-​2-​carboxylic acid​, hydrochloride (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Ceftiofur HCl (U-67279A) is a cephalosporin antibiotic, used to treat both Gram-positive and Gram-negative bacteria infection.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

Isomeric SMILES

CO/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)CSC(=O)C4=CC=CO4)C(=O)O.Cl

Molecular Weight

560.02

Reaxy-Rn

38065090

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=38065090&ln=