CP-547632 TFA - ≥98% , CAS No.C658877

CAS: C658877 Cat. No.: C658877 Formula: C₂₂H₂₅BrF₅N₅O₅S Molecular Weight: 646.43

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Argon charged,Desiccated

Shipped In

Wet ice

Overview

CP-547632 TFA is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC 50 s of 11 nM and 9 nM, respectively. CP-547632 TFA is selective for VEGFR2 and bFGF over EGFR , PDGFRβ , and related tyrosine kinases (TKs). CP-547632

Appearance:Solid

IC50& Target:VEGFR2 11 nM (IC 50 ) FGFR 9 nM (IC 50 )

In Vitro:CP-547632 TFA (1-1000 nM; 1 hours) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion, with an IC 50 value of 6 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot

In Vivo:CP-547632 TFA (p.o.; 6.25-100mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts. CP-547632 TFA (oral; 50mg/kg; a single oral dose) yieldes plasma concentrations above 500 ng/ml for

Biological Activity:CP-547632 TFA is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC 50 s of 11 nM and 9 nM, respectively. CP-547632 TFA is selective for VEGFR2 and bFGF over EGFR , PDGFRβ , and related tyrosine kinases (TKs). CP-547632

Specifications

Specifications & Purity

≥98%

Storage

Store at 2-8°C,Argon charged,Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

Canonical Smiles

FC(F)(C(O)=O)F.O=C(NC1=C(C(N)=O)C(OCC2=C(F)C=C(Br)C=C2F)=NS1)NCCCCN3CCCC3

Molecular Weight

646.43

Chemical and Physical Properties

• Solubility: DMSO : 150 mg/mL (232.04 mM; Need ultrasonic)

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is C658877, the molecular formula is C22H25BrF5N5O5S, and the molecular weight is 646.43 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.