D-3263 hydrochloride - ≥98% , CAS No.1008763-54-9

CAS: 1008763-54-9 Cat. No.: D650364 Molecular Weight: 409.95 PubChem CID: 49787136

GRADE & PURITY ≥98%

Synonyms

3-(2-Amino-ethyl)-1(R)-((2(S)-isopropyl-5(R)-methyl cyclohexanecarbonyl))-5-methoxy-1,3-dihydro-benzoimidazol-2-one hydrochloride | UNII-R82GTC01OB | 1008763-54-9 | AKOS032945009 | D-3263 hydrochloride | HY-16162A | F85439 | R82GTC01OB | EC D-3263 HCl | 3

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist.

In Vitro

D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. D-3263 hydrochloride may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Synonyms

3-(2-Amino-ethyl)-1(R)-((2(S)-isopropyl-5(R)-methyl cyclohexanecarbonyl))-5-methoxy-1, 3-dihydro-benzoimidazol-2-one hydrochloride | UNII-R82GTC01OB | 1008763-54-9 | AKOS032945009 | D-3263 hydrochloride | HY-16162A | F85439 | R82GTC01OB | EC D-3263 HCl | 3

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist.

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CC1CCC(C(C1)C(=O)N2C3=C(C=C(C=C3)OC)N(C2=O)CCN)C(C)C.Cl
• IUPAC Name: 3-(2-aminoethyl)-5-methoxy-1-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]benzimidazol-2-one;hydrochloride
• InChIKey: DYMRNRVXSXCQHZ-UANXYBPYSA-N
• INCHI: 1S/C21H31N3O3.ClH/c1-13(2)16-7-5-14(3)11-17(16)20(25)24-18-8-6-15(27-4)12-19(18)23(10-9-22)21(24)26;/h6,8,12-14,16-17H,5,7,9-11,22H2,1-4H3;1H/t14-,16+,17-;/m1./s1
• Isomeric SMILES: C[C@@H]1CC[C@H]([C@@H](C1)C(=O)N2C3=C(C=C(C=C3)OC)N(C2=O)CCN)C(C)C.Cl
• Alternate CAS: 1008763-54-9
• PubChem CID: 49787136
• Molecular Weight: 409.95

Chemical and Physical Properties

• Solubility: DMSO : 140 mg/mL (341.51 mM; Need ultrasonic)
• Molecular Weight: 409.900 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 409.213 Da
• Monoisotopic Mass: 409.213 Da
• Topological Polar Surface Area: 75.900 Ų
• Heavy Atom Count: 28
• Formal Charge: 0
• Complexity: 553.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3