DCOIT - Moligand™, 10 mM in DMSO , CAS No.64359-81-5

CAS: 64359-81-5 Cat. No.: D1500728 Formula: C₁₁H₁₇Cl₂NOS Molecular Weight: 282.22 EC Number: 264-843-8

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

DCOIT is a representative isothiazolinone that stimulates the gonadotropin-releasing hormone receptor ( GnRHR )-mediated synthesis of follicle-stimulating hormone and luteinizing hormone in the brain. DCOIT interferes with G protein-coupled receptors, MAPK and Ca 2+ signaling cascades.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Names and Identifiers

• Isomeric SMILES: CCCCCCCCN1C(=O)C(=C(S1)Cl)Cl
• RTECS: NX8157075
• Molecular Weight: 282.22
• Reaxy-Rn: 1110842
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1110842&ln=

Chemical and Physical Properties

• x_melt_point_char: 42 °C

References

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2. Tongtong Ding, Luyao Xu, Xiangting Liu, Liang Ma, Yingxin Cui, Dalong Li, Xiuhua Sun, Changlu Gao.  (2022)  A Cu2O-based marine antifouling coating with controlled release of copper ion mediated by amphiphilic PLMA-b-PDMAEMA copolymers.  PROGRESS IN ORGANIC COATINGS,      [PMID:] [10.1016/j.porgcoat.2022.107003]

3. Abid Ali, Lina Song, Jiankun Hu, Jingxian Jiang, Qingqing Rao, Muhammad Shoaib, Shah Fahad, Yongjie Cai, Xiaoli Zhan, Fengqiu Chen, Qinghua Zhang.  (2020)  Synthesis and characterization of caprolactone based polyurethane with degradable and antifouling performance.  CHINESE JOURNAL OF CHEMICAL ENGINEERING,      [PMID:] [10.1016/j.cjche.2020.11.007]

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6. Shuqing Wei, Guangling He, Yuhao Yue, Qianju Liu, Xinhao Liu, Liangmin Yu, Lei Dong.  (2025)  Construction and properties of hydrogel microlayer on the surface of water-based self-polishing antifouling resin coating.  PROGRESS IN ORGANIC COATINGS,      [PMID:] [10.1016/j.porgcoat.2025.109259]

7. Jiayin Li, Guangmeng Chen, Shuaipeng Wang, Jinyue Dai, Shuan Liu, Guangming Lu, Weiwei Zhao, Xiaoqing Liu.  (2025)  Sea-water degradable self-polishing epoxy thermosets for antifouling coatings.  PROGRESS IN ORGANIC COATINGS,      [PMID:] [10.1016/j.porgcoat.2025.109162]

8. Junqiao Zhou, Jiayin Li, Cong Cheng, YuJuan Yao, Yu Li, Hao Liu, Laiyan Wu.  (2024)  Unraveling the binding behavior of the antifouling biocide 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one with human serum albumin: Multi-spectroscopic, atomic force microscope, computational simulation, and esterase activity.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38906347] [10.1016/j.ijbiomac.2024.133266]

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