Dexelvucitabine - 10mM in DMSO , Human immunodeficiency virus type 1 reverse transcriptase inhibitor, CAS No.134379-77-4, Human immunodeficiency virus type 1 reverse transcriptase inhibitor

CAS: 134379-77-4 Cat. No.: D656143 Formula: C₉H₁₀FN₃O₃ Molecular Weight: 227.19

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Dexelvucitabine (Reverset; d-d4FC), a Cytidine analog, is an orally active nucleoside reverse transcriptase inhibitor. Dexelvucitabine is a powerful agent against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in the viral polymerase. Dexelvucitabine is a 2′-Deoxycytidine antiretroviral agent

In Vivo

Dexelvucitabine (Reverset; d-d4FC; 33.3 mg/kg by i.v. or p.o.) has distribution and elimination half-lives (t 1/2α and t 1/2β , respectively) of 0.7 and 3.6 h in monkeys, respectively. The C max ranges from 21.1 to 47.5 μM. Dexelvucitabine has a favorable pharmacokinetic profile with a long half-life (4.71 and 10.75 h after administration by the intravenous [i.v.] and oral [p.o.] routes, respectively) in woodchucks. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:HIV-1

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Dexelvucitabine (Reverset; d-d4FC), a Cytidine ( HY-B0158 ) analog, is an orally active nucleoside reverse transcriptase inhibitor. Dexelvucitabine is a powerful agent against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Human immunodeficiency virus type 1 reverse transcriptase inhibitor

Product Properties

• alogp: -1.3

Names and Identifiers

• Isomeric SMILES: C1=C[C@@H](O[C@@H]1CO)N2C=C(C(=NC2=O)N)F
• Alternate CAS: 134379-77-4
• MeSH Entry Terms: 2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine;2',3'-dideoxy-2',3'-didehydro-beta-D-5-fluorocytidine;2',3'-dideoxy-2',3'-didehydro-beta-L-5-fluorocytidine;2(1H)-Pyrimidinone, 4-amino-1-((2S,5R)-2,5-dihydro-5-(hydroxymethyl)-2-furanyl)-5-fluoro-;4-amino-5-
• Molecular Weight: 227.19
• Reaxy-Rn: 24713405
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24713405&ln=

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 134379-77-4, the molecular formula is C9H10FN3O3, and the molecular weight is 227.19 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.