Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Ethambutol is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases .Target: Antibacterial Ethambutol directly affects two polymers , arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis. In M. smegmatis, Ethambutol inhibits synthesis of arabinan completely and inhibits AG synthesis most likely as a consequence of this; more than 50% of the cell arabinan is released from the bacteria following Ethambutol treatment, whereas no galactan is released. Ethambutol main targets against embB gene product in M. avium. Ethambutol induces 60% changes in the embB gene in M. tuberculosis resistant mutantsEthambutol is potency against M. tuberculosis (H37Rv) with MIC of 0.5 μg/mL in vitro . Ethambutol is efficient on treatment of mycobacterial-infected macrophages. When M. tuberculosis infected macrophages are treated with 6 μg/mL Ethambutol, the log CFUs following treatment for 3 days is 4.17, while value in control group is 4.8. The MICs for M. avium (MTCC 1723) and M. smegmatis (MTCC 6) are 15 μg/mL and 0.18 μg/mL, respectively. Ethambutol is efficient in animal model. 100 mg/kg Ethambutol given orally 15 days post i.v. infection 1 ×/week for 5 weeks, induces a lower log CFU compared with untreatment (4.59 vs 5.07) .
| pKa | pKa: 9.59 (Predicted) |
|---|
| Isomeric SMILES | CC[C@@H](CO)NCCN[C@@H](CC)CO |
|---|---|
| Alternate CAS | 3577-94-4 |
| Molecular Weight | 204.31 |
| Beilstein | 6312870 |
| Reaxy-Rn | 1903969 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1903969&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Refractive Index | n20D1.48 (Predicted) |
|---|---|
| Boil Point(°C) | ~345.3° C at 760 mmHg (Predicted) |
| Melt Point(°C) | 199-204° C |
| 1. Kuanxia Ma, Lushan Liang, Xie Zhou, Weiguo Tan, Ou Hu, Zuanguang Chen. (2020) A Redox-induced Dual-mode Colorimetric and Fluorometric Method based on N-CDs and MnO2 for Determination of Isoniazid in Tablets and Plasma Samples. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:33161268] [10.1016/j.saa.2020.119097] |
| 2. Jiang Xiuzhi, Cao Dan, Xu Bihan, Yuan Xin, Xiang Yanghui, Wu Tiantian, Zhang Ying. (2025) Essential Oils and their Active Constituents Effective against Non-growing Mycobacterium intracellulare. BMC Complementary Medicine and Therapies, 25 (1): (1-10). [PMID:40165207] [10.1186/s12906-025-04855-5] |
| 3. Zhang Zhiyang, Xu Nixi, Tao Zean, Liang Yun, Jin Lixia, Li Zhuoxuan, Cao Yuanwu, Jiang Chang, Chen Zixian. (2025) Ccn1 Mediates Pyroptosis and Purine Metabolism Pattern Shifts in a High-Uric Acid Microenvironment After Spinal Cord Injury. MOLECULAR NEUROBIOLOGY, 63 (1): (229). [PMID:41324748] [10.1007/s12035-025-05529-6] |
| 4. Yuwei Qiu, Xu Dong, Dan Cao, Xiuzhi Jiang, Zhongkang Ji, Pusheng Xu, Yi Li, Kaijing Xu, Ying Zhang. (2026) Mutations in the ubiA gene are the major mechanism of ethambutol resistance in Mycobacterium avium. Microbiology Spectrum, [PMID:] [10.1128/spectrum.03151-25] |
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