Firibastat - 10mM in Water , Aminopeptidase A inhibitor, CAS No.648927-86-0, Aminopeptidase A inhibitor

CAS: 648927-86-0 Cat. No.: F656797 Formula: C₈H₂₀N₂O₆S₄ Molecular Weight: 368.51 EC Number: 817-496-7 PubChem CID: 24851355

GRADE & PURITY 10mM in Water

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Firibastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor ( K i =200 nM). Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats.

In Vivo

When given orally, Firibastat (0.1-30 mg/kg; p.o.) crosses the gastrointestinal and blood-brain barriers, enters the brain, and generates two active molecules of EC33 which inhibit brain APA activity, blocking brain angiotensin III formation, and decrease blood pressure for several hours in hypertensive rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Normotensive and hypertensive DOCA-salt rats Dosage: 0.1-30 mg/kg Administration: P.o. Result: Resulting in a dose-dependent decrease in mean arterial blood pressure (MABP).

Specifications

Specifications & Purity

10mM in Water

Biochemical and Physiological Mechanisms

Firibastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor ( K i =200 nM). Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III a

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Aminopeptidase A inhibitor

Product Properties

• alogp: -6.9

Names and Identifiers

• Isomeric SMILES: C(CS(=O)(=O)O)[C@@H](CSSC[C@H](CCS(=O)(=O)O)N)N
• Alternate CAS: 648927-86-0
• PubChem CID: 24851355
• MeSH Entry Terms: 4,4'-dithio(bis(3-aminobutyl sulfonic acid));firibastat;RB 150;RB-150;RB150;RB150 cpd
• Molecular Weight: 368.51

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 648927-86-0, the molecular formula is C8H20N2O6S4, and the molecular weight is 368.51 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.