FlAsH-EDT2 - ≥95% , CAS No.212118-77-9

CAS: 212118-77-9 Cat. No.: F332805 Molecular Weight: 664.5

GRADE & PURITY ≥95%

Synonyms

UNII-Z8CH38Y9L3 | 4',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein | FLASH-EDT2 | FlAsH-EDT-2 | SCHEMBL2266085 | DTXSID90431400 | J-013919 | 4',5'-bis(1,3,2-dithiarsolan-2-yl)-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one | FlAsH EDT2 | FT-0668535

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

FlAsH-EDT2 is a fluorescence probe for labeling proteins. The Fluorescein Arsenical Hairpin Binder (FlAsH) method is presented for fluorescence labeling of proteins in living cells. Labeling proteins with the membrane-permeant fluorogenic biarsenical dye fluorescein arsenical hairpin binder-ethanedithiol (FlAsH-EDT2). The membrane-permeant fluorogenic biarsenicals FlAsH-EDT2 and ReAsH-EDT2 can be prepared in good yields by a straightforward two-step procedure from the inexpensive precursor dyes fluorescein and resorufin. FlAsH-EDT2 binds covalently to a tetracysteine sequence (CCPGCC).

Specifications

Synonyms

UNII-Z8CH38Y9L3 | 4', 5'-bis(1, 3, 2-dithioarsolan-2-yl)fluorescein | FLASH-EDT2 | FlAsH-EDT-2 | SCHEMBL2266085 | DTXSID90431400 | J-013919 | 4', 5'-bis(1, 3, 2-dithiarsolan-2-yl)-3', 6'-dihydroxyspiro[2-benzofuran-3, 9'-xanthene]-1-one | FlAsH EDT2 | FT-0668535

Specifications & Purity

≥95%

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%

Product Properties

• Excitation and Emision Ranges: λex 508 nm,λem 528 nm

Names and Identifiers

• Pubchem Sid: 488196337
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488196337
• Canonical Smiles: C1CS[As](S1)C2=C(C=CC3=C2OC4=C(C35C6=CC=CC=C6C(=O)O5)C=CC(=C4[As]7SCCS7)O)O
• IUPAC Name: 4',5'-bis(1,3,2-dithiarsolan-2-yl)-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
• InChIKey: AJNUQUGWNQHQDJ-UHFFFAOYSA-N
• INCHI: 1S/C24H18As2O5S4/c27-17-7-5-15-21(19(17)25-32-9-10-33-25)30-22-16(6-8-18(28)20(22)26-34-11-12-35-26)24(15)14-4-2-1-3-13(14)23(29)31-24/h1-8,27-28H,9-12H2
• Isomeric SMILES: C1CS[As](S1)C2=C(C=CC3=C2OC4=C(C35C6=CC=CC=C6C(=O)O5)C=CC(=C4[As]7SCCS7)O)O
• Molecular Weight: 664.5
• Reaxy-Rn: 10621881
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10621881&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Benzopyrans
      • Subclass 1-benzopyrans
        • Level5 Dibenzopyrans
          • Level6 Xanthenes

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Benzopyrans
• Subclass: 1-benzopyrans
• Intermediate Tree Nodes: Dibenzopyrans
• Direct Parent: Xanthenes
• Alternative Parents: Diarylethers Phthalides Benzofuranones Isobenzofurans 1-hydroxy-2-unsubstituted benzenoids Trivalent organic arsenic compounds Lactones Carboxylic acid esters Oxygen-containing organoarsenic compounds Oxacyclic compounds Organoarsenic sulfides Organic metalloid salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Xanthene - Diaryl ether - Benzofuranone - Isobenzofuranone - Phthalide - Isocoumaran - Isobenzofuran - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Benzenoid - Carboxylic acid ester - Lactone - Trivalent organic arsenic compound - Sulfur-containing organoarsenic compound - Organoarsenic sulfide - Oxygen-containing organoarsenic compound - Ether - Organic metalloid salt - Carboxylic acid derivative - Oxacycle - Hydrocarbon derivative - Organooxygen compound - Organoarsenic compound - Organic metalloid moeity - Organic oxygen compound - Organic oxide - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in chloroform.
• Sensitivity: light sensitive；Moisture sensitive
• Boil Point(°C): 849.8° C at 760 mmHg (Predicted)
• Melt Point(°C): 169-172° C (dec.)
• Molecular Weight: 664.500 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 2
• Exact Mass: 663.847 Da
• Monoisotopic Mass: 663.847 Da
• Topological Polar Surface Area: 177.000 Ų
• Heavy Atom Count: 35
• Formal Charge: 0
• Complexity: 784.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

XLogP3