Potent, selective PKC inhibitor. Potent GSK-3 inhibitor. Potent 5-HT3 antagonist.
GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.
A highly selective inhibitor of all PKC isoforms and slight inhibitor of GSK-3
| CAS | 133052-90-1 |
|---|---|
| Synonyms | NCGC00024760-07 | Go 6850 | KBio2_003068 | Bio2_000900 | Bisindolylmaleimide I (GF 109203X) | MFCD00236428 | AKOS024458625 | SCHEMBL338086 | 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE | IDI1_002175 | 1H-Pyrrole-2, |
| Specifications & Purity | Moligand™, ≥99% |
| Storage | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor. |
| Pubchem Sid | 508812739 |
| Solubility | Soluble in DMSO (~1 mg/ml), DMF (10 mg/ml; warm to 40°C & vortex well), and 1:10 DMSO:PBS (pH 7.2) (~0.1 mg/ml). Insoluble in water. |
| Sensitivity | Heat Sensitive |
| Mdl Number | MFCD00236428 |
| EC Number | 603-702-0 |
| PubChem CID | 2396 |
| Molecular Formula | C25H24N4O2 |
