4,4′-(Hexafluoroisopropylidene)bis(p-phenyleneoxy)dianiline (HFBAPP) - Moligand™,≥99% , K 2P10.1 activator; K 2P2.1 activator, CAS No.69563-88-8, K 2P10.1 activator; K 2P2.1 activator

CAS: 69563-88-8 Cat. No.: H1507157 Formula: C₂₇H₂₀F₆N₂O₂ Molecular Weight: 518.45 EC Number: 626-703-8

GRADE & PURITY Moligand™, ≥99%

Storage

Room temperature

Shipped In

Normal

Specifications

Specifications & Purity

Moligand™,≥99%

Biochemical and Physiological Mechanisms

TREK1 and TREK2 channel activators (EC50=0.76 μ M in Rb efflux assay in CHO cells expressing TREK1). Compared with TRAAK, TASK3, and a series of other potassium ion channels, TREK1/2 exhibits selectivity. Hyperpolarized membrane potential of dorsal root g

Storage

Room temperature

Shipped In

Normal

Grade

Moligand™

Action Type

ACTIVATOR

Mechanism of action

K 2P10.1 activator; K 2P2.1 activator

Purity

≥99%

Names and Identifiers

• Canonical Smiles: NC1=CC=C(OC2=CC=C(C=C2)C(C2=CC=C(OC3=CC=C(N)C=C3)C=C2)(C(F)(F)F)C(F)(F)F)C=C1
• IUPAC Name: 4,4'-{(1,1,1,3,3,3-Hexafluoropropane-2,2-diyl)bis[(4,1-phenylene)oxy]}dianiline
• InChIKey: HHLMWQDRYZAENA-UHFFFAOYSA-N
• INCHI: InChI=1S/C27H20F6N2O2/c28-26(29,30)25(27(31,32)33,17-1-9-21(10-2-17)36-23-13-5-19(34)6-14-23)18-3-11-22(12-4-18)37-24-15-7-20(35)8-16-24/h1-16H,34-35H2
• Isomeric SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)OC3=CC=C(C=C3)N)(C(F)(F)F)C(F)(F)F)OC4=CC=C(C=C4)N
• WGK Germany: 3
• RTECS: CY1213000
• Molecular Weight: 518.45
• Reaxy-Rn: 8879443
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8879443&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Diphenylmethanes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Diphenylmethanes
• Intermediate Tree Nodes: Not available
• Direct Parent: Diphenylmethanes
• Alternative Parents: Diphenylethers Diarylethers Phenoxy compounds Phenol ethers Aniline and substituted anilines Primary amines Organopnictogen compounds Organofluorides Hydrocarbon derivatives Alkyl fluorides
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Diphenylmethane - Diphenylether - Diaryl ether - Phenoxy compound - Phenol ether - Aniline or substituted anilines - Ether - Amine - Primary amine - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Alkyl fluoride - Organic oxygen compound - Hydrocarbon derivative - Alkyl halide - Organopnictogen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Insoluble in water, soluble in methanol
• x_melt_point_char: 159-163°C

References

1. Lidong Cao, Yaqing Wen, Xingzhong Fang, Guofei Chen.  (2023)  Synthesis of highly thermoplastic polyamide-imides with high transparency and low coefficient of thermal expansion.  POLYMER,      [PMID:] [10.1016/j.polymer.2023.126093]

2. Chaoying Liao, Zhaozhu Zhang, Yaohui He, Junya Yuan, Mingming Yang, Peilong Li, Wei Jiang, Yongmin Liang, Weimin Liu.  (2025)  Bioinspired Antiwear Poly(urea-imide) Composites: Influence of Tribology on Polymer Crystal Structure.  Small,      [PMID:39780741] [10.1002/smll.202408249]

3. Chaoying Liao, Zhaozhu Zhang, Yaohui He, Mingming Yang, Junya Yuan, Peilong Li, Yongmin Liang.  (2025)  Liquid metal microcapsules induced formation of dual-layer tribofilm for enhanced wear resistance in fabric composites.  TRIBOLOGY INTERNATIONAL,      [PMID:] [10.1016/j.triboint.2025.110598]

4. Siyao Wang, Tianyou Li, Zeyuan Gao, Lu Bai, Fangxu Fan, Shuang Zhang, Peiyao Niu, Jinyu Li, Gaohong He, Canghai Ma.  (2026)  Synergistic ether-flexible and bulky rigid diamine copolymers enable carbon molecular sieve membranes with enhanced C2H4/C2H6 separation.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2026.125846]

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at room temperature.

How is this product shipped?

This product ships under standard ambient conditions. No temperature-controlled packaging is required.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 69563-88-8. InChIKey HHLMWQDRYZAENA-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.