IMD-0560 - 10mM in Ethanol , CAS No.439144-66-8

CAS: 439144-66-8 Cat. No.: I654919 Molecular Weight: 428.12 PubChem CID: 11464503

GRADE & PURITY 10mM in Ethanol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

IMD-0560 is a novel IκB kinase β inhibitor.

In Vitro

Pretreatment with IMD-0560 inhibits both IκBα degradation and p65 phosphorylation induced by TNFα. IMD-0560 also suppresses TNFα-induced transcriptional activity. Pretreatment with IMD-0560 strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The tumor size is reduced in the IMD-0560-treated groups in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560. Zygoma destruction is significantly suppressed in the IMD-0560-treated groups compare to the control groups. Although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group, the inhibitory effect of each treatment on zygoma destruction is similar . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IKKβ

Specifications

Specifications & Purity

10mM in Ethanol

Biochemical and Physiological Mechanisms

IMD-0560 is a novel IκB kinase β inhibitor.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C1=CC(=C(C=C1C(F)(F)F)NC(=O)C2=C(C=CC(=C2)Br)O)C(F)(F)F
• Alternate CAS: 439144-66-8
• PubChem CID: 11464503
• MeSH Entry Terms: IMD-0560;N-(2,5-bis(trifluoromethyl)phenyl)-5-bromo-2-hydroxybenzamide
• Molecular Weight: 428.12