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· · COA & SDS available for every product · Same-day shipping on in-stock items LarotrectinibFor - Moligand™, ≥97% , Inhibitor of neurotrophic receptor tyrosine kinase 1, CAS No.1223403-58-4, Inhibitor of neurotrophic receptor tyrosine kinase 1
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97% Synonyms
NYNZQNWKBKUAII-KBXCAEBGSA-N | DB14723 | Q27081513 | ARRY470 | ARRY-470 | ARRY-470; larotrectinib | AS-35231 | Larotrectinib [INN] | larotrectinibum | Vitrakvi | 1223403-58-4 | (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin -1-yl)pyrazolo[1,5-a]pyrimidin-3
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥97% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
NYNZQNWKBKUAII-KBXCAEBGSA-N | DB14723 | Q27081513 | ARRY470 | ARRY-470 | ARRY-470; larotrectinib | AS-35231 | Larotrectinib [INN] | larotrectinibum | Vitrakvi | 1223403-58-4 | (S)-N-(5-((R)-2-(2, 5-difluorophenyl)pyrrolidin -1-yl)pyrazolo[1, 5-a]pyrimidin-3
Specifications & Purity
Moligand™, ≥97%
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Inhibitor of neurotrophic receptor tyrosine kinase 1
Product Properties Names and Identifiers Pubchem Sid 504770672 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504770672 Canonical Smiles C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F IUPAC Name (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide InChIKey NYNZQNWKBKUAII-KBXCAEBGSA-N INCHI 1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1 Isomeric SMILES C1C[C@@H](N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CC[C@@H](C4)O)C5=C(C=CC(=C5)F)F Alternate CAS 1223403-58-4 MeSH Entry Terms (3S)-N-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide;ARRY-470;ARRY470;BAY-2757556;BAY2757556;larotrectinib;LOXO-101;LOXO101;N-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo(1,5-a)pyrimidin- Molecular Weight 428.4 Reaxy-Rn 36507359 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=36507359&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Pyrrolidines Subclass Phenylpyrrolidines Intermediate Tree Nodes Not available Direct Parent Phenylpyrrolidines Alternative Parents Pyrazolo[1,5-a]pyrimidines Dialkylarylamines Pyrrolidinecarboxamides Fluorobenzenes Aminopyrimidines and derivatives Imidolactams Aryl fluorides Pyrroles Pyrazoles Heteroaromatic compounds Ureas Secondary alcohols Azacyclic compounds Organofluorides Organic oxides Hydrocarbon derivatives Carbonyl compounds Molecular Framework Aromatic heteropolycyclic compounds Substituents 2-phenylpyrrolidine - Pyrazolo[1,5-a]pyrimidine - Pyrazolopyrimidine - Pyrrolidine carboxylic acid or derivatives - Dialkylarylamine - Pyrrolidine-1-carboxamide - Aminopyrimidine - Fluorobenzene - Halobenzene - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Pyrimidine - Imidolactam - Benzenoid - Pyrrole - Heteroaromatic compound - Pyrazole - Azole - Urea - Tertiary amine - Secondary alcohol - Azacycle - Amine - Organohalogen compound - Organic oxide - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Organofluoride - Organonitrogen compound - Alcohol - Organooxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as phenylpyrrolidines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyrrolidine ring through a CC or CN bond. Pyrrolidine is a five-membered saturated aliphatic heterocycle with one nitrogen atom and four carbon atoms. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Molecular Weight 428.400 g/mol XLogP3 1.700 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 7 Rotatable Bond Count 3 Exact Mass 428.177 Da Monoisotopic Mass 428.177 Da Topological Polar Surface Area 86.000 Ų Heavy Atom Count 31 Formal Charge 0 Complexity 659.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 2 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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