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Liarozole (R75251; R85246) is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA) . Liarozole inhibits the cytochrome P450 ( CYP26 )-dependent 4-hydroxylation of retinoic acid ( IC 50 =7 μM), resulting in increased tissue levels of retinoic acid. Liarozole shows antitumoral properties.
| CAS | 115575-11-6 |
|---|---|
| Concentration | 10 mM in DMSO |
| Specifications & Purity | Moligand™, 10 mM in DMSO |
| Storage | Protected from light,Store at -80°C |
| Shipped In | Dry ice packs + Cold packs |
| Product Description | Liarozole (R75251; R85246) is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA) . Liarozole inhibits the cytochrome P450 ( CYP26 )-dependent 4-hydroxylation of retinoic acid ( IC 50 =7 μM), resulting in increased tissue levels of retinoic acid. Liarozole shows antitumoral properties. |
| Molecular Formula | C17H13ClN4 |