10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Licochalcone B is an extract from the root of Glycyrrhiza uralensis . Licochalcone B inhibits amyloid β ( 42 ) self-aggregation ( IC 50 =2.16 μM) and disaggregate pre-formed Aβ 42 fibrils, reduce metal-induced Aβ 42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction
In Vitro
Licochalcone B (IC 50 : 2.16 μM) inhibits self-mediated Aβ42 aggregation and disaggregates Aβ42 pre-formed fibrils. Licochalcone B (0-12 μM, 48 h) reduces the ROS generation and protects cells from H 2 O 2 -induced cell death in SH-SY5Y cells. Licochalcone B (10 μM, 1 h) inhibits LPS-induced NF-κB activation in RAW264.7 cells. Licochalcone B (10 μM, 1 h) inhibits the LPS-induced phosphorylation of NF-κB p65 at serine 276, and inhibited the expression of TNFα and MCP-1. Licochalcone B (0-20 μM, 24 or 48 h) inhibits human NSCLC cell growth. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: RAW264.7 cells Concentration: 10 µM Incubation Time: 1 h Result: Inhibited the phosphorylation of NF-κB at serine 276 but not at serine 536.
In Vivo
Licochalcone B (1-25 mg/kg, oral gavage) alleviates oxidative stress of hepatotoxicity in mice induced by CCl 4. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice induced by CCl 4Dosage: 1, 5, 25 mg/kg Administration: Oral gavage. Result: Elevated the levels of SOD and GSH, and reduced the GSSG levels.
IC50& Target:NLRP3
| Isomeric SMILES | COC1=C(C=CC(=C1O)O)/C=C/C(=O)C2=CC=C(C=C2)O |
|---|---|
| PubChem CID | 5318999 |
| Molecular Weight | 286.28 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Flash Point(°F) | Not applicable |
|---|---|
| Flash Point(°C) | Not applicable |
