Litronesib - 10mM in DMSO , Kinesin-like protein 1 inhibitor, CAS No.910634-41-2, Kinesin-like protein 1 inhibitor

CAS: 910634-41-2 Cat. No.: L656183 Formula: C₂₃H₃₇N₅O₄S₂ Molecular Weight: 511.70 PubChem CID: 25167017

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity

In Vitro

Litronesib (LY2523355) is a selective Eg5 inhibitor. Litronesib (25 nM) induces cancer cells to death during mitotic arrest, and this needs sustained activation of spindle-assembly checkpoint (SAC). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) shows antitumor activity in a dose-dependently, and causes a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Eg5

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Kinesin-like protein 1 inhibitor

Product Properties

• alogp: 3.1

Names and Identifiers

• Isomeric SMILES: CCNCCS(=O)(=O)NC[C@@]1(N(N=C(S1)NC(=O)C(C)(C)C)C(=O)C(C)(C)C)C2=CC=CC=C2
• Alternate CAS: 910634-41-2
• PubChem CID: 25167017
• MeSH Entry Terms: (-)-N-(4-(2,2-dimethyl-propionyl)-5-((2-ethylamino-ethanesulfonylamino)-methyl)-5- phenyl-4,5-dihydro-(1,3,4)thiadiazol-2-yl)-2,2-dimethyl-propionamide;(R)-N-(4-(2,2-dimethyl-propionyl)-5-((2-ethylamino-ethanesulfonylamino)-methyl)-5- phenyl-4,5-dihydro-(
• Molecular Weight: 511.70

Associated Targets(Human)

KIF11 Tchem Kinesin-like protein KIF11 (2 Activities)

Discover Target: KIF11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 910634-41-2, the molecular formula is C23H37N5O4S2, and the molecular weight is 511.70 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.