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LY 404187 - Moligand™, ≥98% , Allosteric modulator of GluA1;Allosteric modulator of GluA2;Allosteric modulator of GluA3;Allosteric modulator of GluA4, CAS No.211311-95-4, Allosteric modulator of GluA1;Allosteric modulator of GluA2;Allosteric modulator of GluA3;Allosteric modulator of GluA4

CAS: 211311-95-4 Cat. No.: L274875 Molecular Weight: 342.46
COA
LY 404187 - Moligand™, ≥98% CAS No(211311-95-4) by Aladdin Scientific
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
75W6I8W6OU | A879241 | N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide | N-[2-[4-(4-cyanophenyl)phenyl]propyl]propane-2-sulfonamide | SCHEMBL2134262 | 2-Propanesulfonamide, N-(2-(4'-cyano(1,1'-biphenyl)-4-yl)propyl)- | Q27083110 | SR-01000
Storage
Store at 2-8°C
Shipped In
Wet ice
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 ·  off list, applied to all prices below.
Size
Status
Price
Qty
1mg
L274875-1mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$82.90
5mg
L274875-5mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$199.90
10mg
L274875-10mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$329.90
50mg
L274875-50mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$823.90
100mg
L274875-100mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$1,360.90
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews
🧪

Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Shipped at Room Temperature. Store at +4°C.

Specifications

Synonyms
75W6I8W6OU | A879241 | N-[2-(4'-Cyano[1, 1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide | N-[2-[4-(4-cyanophenyl)phenyl]propyl]propane-2-sulfonamide | SCHEMBL2134262 | 2-Propanesulfonamide, N-(2-(4'-cyano(1, 1'-biphenyl)-4-yl)propyl)- | Q27083110 | SR-01000
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
Novel, selective AMPA receptor positive allosteric modulator (IC 50 values\xa0of 0.15, 0.21, 1.66 and 5.65 μ M for GluA2 i , GluA4 i , GluA3 i and GluA1 i respectively).
Storage
Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
ALLOSTERIC MODULATOR
Mechanism of action
Allosteric modulator of GluA1;Allosteric modulator of GluA2;Allosteric modulator of GluA3;Allosteric modulator of GluA4
Note
Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Purity
≥98%
Names and Identifiers
Canonical SmilesCC(C)S(=O)(=O)NCC(C)C1=CC=C(C=C1)C2=CC=C(C=C2)C#N
IUPAC NameN-[2-[4-(4-cyanophenyl)phenyl]propyl]propane-2-sulfonamide
InChIKeyHOQAVGZLYRYHSO-UHFFFAOYSA-N
INCHI1S/C19H22N2O2S/c1-14(2)24(22,23)21-13-15(3)17-8-10-19(11-9-17)18-6-4-16(12-20)5-7-18/h4-11,14-15,21H,13H2,1-3H3
Isomeric SMILES CC(C)S(=O)(=O)NCC(C)C1=CC=C(C=C1)C2=CC=C(C=C2)C#N
Molecular Weight 342.46
Reaxy-Rn 8781032
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8781032&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassBenzene and substituted derivatives
SubclassBiphenyls and derivatives
Intermediate Tree Nodes Not available
Direct ParentBiphenylcarbonitriles
Alternative Parents Monocyclic monoterpenoids  Aromatic monoterpenoids  Benzonitriles  Organosulfonamides  Organic sulfonamides  Aminosulfonyl compounds  Nitriles  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Biphenylcarbonitrile - P-cymene - Aromatic monoterpenoid - Monocyclic monoterpenoid - Monoterpenoid - Benzonitrile - Organic sulfonic acid amide - Organosulfonic acid amide - Aminosulfonyl compound - Organic sulfonic acid or derivatives - Sulfonyl - Organosulfonic acid or derivatives - Nitrile - Carbonitrile - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organosulfur compound - Organic nitrogen compound - Organic oxygen compound - Cyanide - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as biphenylcarbonitriles. These are organic compounds containing an acetonitrile with one hydrogen replaced by a biphenyl group.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
GRIA4 Tclin Glutamate receptor 4 (6 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIA2 Tclin Glutamate receptor 2 (5 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIA3 Tclin Glutamate receptor 3 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIA1 Tclin Glutamate receptor 1 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIA3 Tclin Glutamate receptor ionotropic, AMPA 3 (127 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIA1 Tclin Glutamate receptor ionotropic, AMPA 1 (277 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIA2 Tclin Glutamate receptor ionotropic, AMPA 2 (847 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK-293T (167025 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gria4 Glutamate receptor ionotropic, AMPA 4 (112 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SolubilitySoluble in DMSO to 100mM and in\xa0ethanol to 50mM
Molecular Weight342.500 g/mol
XLogP33.800
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass342.14 Da
Monoisotopic Mass342.14 Da
Topological Polar Surface Area78.300 Ų
Heavy Atom Count24
Formal Charge0
Complexity527.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Solution Calculators
Reviews

Customer Reviews

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