GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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Application Protocols
Item-specific validated protocols: Not provided for this item.
General protocols for small-molecule screening stocks
DMSO stock preparation
Weigh the appropriate amount quickly to minimize atmospheric moisture exposure.
Prepare a concentrated stock (e.g., 10–50 mM) in anhydrous DMSO. Vortex and, if needed, sonicate briefly to fully dissolve. Filter (0.22 µm PTFE) if particulates persist.
Working solution and assay dilution
Dilute the DMSO stock into assay buffer to the desired concentration while vortexing. Maintain final DMSO at 0.1–1% v/v unless your assay tolerates more.
For cell assays, pre-test for cytotoxicity of the vehicle and compound; include vehicle-only controls.
Stability checks
Assess short-term stability at room temperature and typical assay temperatures (e.g., 25–37°C) over the experiment timeframe by LC or UV-HPLC.
Avoid repeated freeze–thaw cycles; aliquot stocks (e.g., 10–50 µL) in low-bind tubes.
Plate handling
Use polypropylene plates for DMSO stocks to minimize adsorption.
Seal plates to limit evaporation; equilibrate to room temperature before opening to prevent condensation.
All parameters above are general guidance and not item-specific specifications; adjust to your assay’s constraints.
Biological Roles
Item-specific biological information
No target class, pathway, or mechanism of action is provided for LY389795 in this listing. Any biological role is therefore unspecified; consult internal data or literature corresponding to PubChem CID 10058694 if applicable.
General guidance for small-molecule library members
Potential uses include probing protein function, modulating enzyme or receptor activity, and serving as a chemotype for structure–activity relationship (SAR) exploration once a biological readout is established.
Before inferring mechanism, confirm identity/purity, verify solubility under assay conditions, and perform orthogonal counter-screens to exclude assay artifacts (fluorescence interference, aggregation, redox cycling, metal chelation).
Important limitations
For research use only. No clinical, diagnostic, or therapeutic claims are made or implied for this material.
Biological potency, selectivity, and ADME/tox properties are not specified for this item; rely on your own experimental determination or documented literature values if the compound identity is independently confirmed.
Buffer Applications
Not typically applicable
LY389795 is a small-molecule library member rather than a buffering reagent. No acid/base pKa or buffer capacity information is provided.
Practical notes (general)
Prepare assay dilutions in established biological buffers (e.g., PBS pH 7.4, HEPES 25–50 mM pH 7.4–7.5, or Tris if compatible with your assay). Maintain low final organic solvent (DMSO/EtOH) content to avoid perturbing buffer pH/ionic strength.
If the compound is ionizable (structure required to confirm), buffer pH can affect solubility and target engagement; run pH controls where relevant.
Green Alternatives
Applicability
As a discovery library compound, LY389795 is not used as a bulk solvent or reagent where greener replacements are typically considered. Therefore, “green alternatives” generally pertain to the choice of dissolution media and assay buffers rather than substitution of the compound itself.
Greener practices for handling small molecules (general)
Prefer ethanol or water–co-solvent systems over DMF when assay-compatible; keep DMSO at the minimum effective final concentration (e.g., ≤0.5–1% v/v).
Use phosphate or HEPES buffers prepared at appropriate ionic strength instead of specialized organic buffers where feasible.
Minimize waste by preparing small, right-sized stock solutions and employing 96/384-well miniaturization to reduce solvent use.
Evaluate compound adsorption to plastics to avoid repeated preparations and excess solvent consumption.
Trade-offs
DMSO remains the most universally effective solvent; greener alternatives (ethanol, aqueous surfactant systems) may compromise solubility or assay performance. Validate alternatives experimentally for your specific target/assay.
Pharmaceutical Uses
Item-specific status
This product is supplied for research use only within small-molecule discovery workflows. It is not certified for clinical, diagnostic, or GMP use.
General context for similar materials
In pharmaceutical R&D, library compounds are used as reference ligands, positive/negative controls in screening cascades, and for early medicinal chemistry hypothesis testing (SAR, selectivity, and liability assessments). They are not excipients and are not intended for administration.
Documentation
Pharmacopeial monographs, residual solvent compliance, nitrosamine risk assessments, and extractables/leachables packages are not provided unless explicitly requested. For any regulated applications, alternative qualified materials are required.
Physical Properties
Item-specific data
Appearance: Not specified for this item; refer to CoA/Spec Sheet.
Melting point (MP): Not specified for this item; refer to CoA/Spec Sheet.
Boiling point (BP): Not specified for this item; refer to CoA/Spec Sheet.
Density: Not specified for this item; refer to CoA/Spec Sheet.
Refractive index: Not specified for this item; refer to CoA/Spec Sheet.
Solubility: Not specified for this item; refer to CoA/Spec Sheet.
LogP / pKa: Not specified for this item; refer to CoA/Spec Sheet.
General guidance for small-molecule library members (literature/practice)
Solubility screening hierarchy: begin with anhydrous DMSO (10–50 mg/mL), then assess miscibility into aqueous assay buffers via serial dilution (final DMSO 0.1–1% v/v typical in biochemical assays). If precipitation occurs, consider co-solvents (DMF, ethanol) at ≤5% v/v, or surfactants (0.01–0.05% Tween-20) when assay-compatible.
If ionizable, aqueous solubility may be increased by pH adjustment: acids dissolve better in basic media; bases in acidic media. Only apply after confirming ionization state (requires structure/pKa data).
Hygroscopicity and polymorphism can impact measured MP and solubility. Verify batch-specific data on the CoA.
Do not treat any generic property values as specifications; rely on the item’s CoA/Spec Sheet for release criteria.
Quality and Grades
Item-specific quality note
Grade/Purity: Moligand™ (as provided). No additional numerical purity or stabilizer information is specified for this item; refer to CoA/Spec Sheet for batch-specific assays.
What Moligand™ typically implies (general information)
Moligand™-grade compounds are intended for small-molecule discovery workflows (e.g., target engagement, ligand screening, and SAR). Emphasis is placed on identity confirmation (NMR/MS), screening-suitable purity, and compatibility with assay stock preparation (e.g., DMSO solubility testing).
Documentation commonly provided includes: identity verification (1H NMR/HRMS), purity by HPLC/UPLC-UV (typical screening acceptance ≥90–95% area; confirm on CoA), and residual solvent limits suitable for research use. These are general expectations and not item-specific specifications.
Key considerations for this item
Identity, purity, residual solvents, and water content: Not specified for this item; refer to CoA/Spec Sheet.
UV cutoff/LC baseline behavior: Not specified for this item; refer to CoA/Spec Sheet.
Stabilizers/inhibitors: None indicated; if present, they will be listed on the CoA.
Suitability: Designed for research screening. For analytical reference standard or GMP-related use, request an enhanced documentation package and confirm specifications meet your needs.
Reaction and Applications
Item-specific application notes
Manufacturer Applications: Not specified in the listing beyond inclusion in a small-molecule/compound library category. No target or mechanism is provided for LY389795.
General research uses for library compounds
Tool/ligand screening: evaluate activity in biochemical, biophysical (SPR, DSF, MST), or cell-based assays to identify hits and characterize SAR.
Panel profiling: compare responses across target families to assess selectivity and off-target liabilities.
Assay development: use as a candidate control if activity is established in-house; confirm identity and potency before adoption.
Not typically used as a synthetic reagent
With structure and reactivity unspecified, LY389795 should be treated primarily as a test article for discovery assays rather than as a building block for chemical synthesis.
Best practices
Confirm identity/purity by orthogonal methods (LC-MS, 1H NMR) upon receipt for critical studies.
Establish a solubility and stability profile in your assay matrix (time, temperature, light, plastic binding) before screening at scale.
Track freeze–thaw cycles for DMSO stocks and avoid prolonged storage at room temperature once in solution.
Reaction Conditions
Not applicable for this listing
No chemical reactivity or transformation context is provided for LY389795, and it is offered as a screening compound rather than a reagent. Consequently, no reaction conditions are recommended.
General precaution
If you intend to derivatize or use LY389795 in synthesis, first obtain and verify the full structure and consult primary literature for conditions specific to its functional groups. Absent such data, Aladdin provides no reaction condition guidance for this item.
Safety and Handling
Item-specific hazard data
Signal Word: Not specified for this item; refer to SDS.
H-Statements / GHS Classification / Pictograms: Not specified for this item; refer to SDS.
General laboratory safety (defer to SDS as authoritative)
Personal protective equipment: lab coat, safety glasses, and appropriate chemically resistant gloves (e.g., nitrile). Handle powders in a fume hood to avoid inhalation of dust/aerosols.
Avoid contact with skin, eyes, and clothing. Prevent inhalation/ingestion. Wash hands thoroughly after handling.
Storage incompatibilities: until functional groups are known, segregate from strong oxidizers, strong acids/bases, and ignition sources. Keep container tightly closed, dry, and well-ventilated.
First aid overview: in case of eye/skin contact, rinse with water for ≥15 minutes; remove contaminated clothing. If inhaled, move to fresh air; if ingested, rinse mouth and seek medical attention. Provide the SDS to medical personnel.
Spills: collect solids by gentle sweeping with minimal dust generation; for solutions, absorb on inert material. Dispose in accordance with institutional and local regulations.
Thermal/photostability: unknown for this item; avoid excessive heat and direct light as a precaution.
For research use only. Not for human or veterinary use.
Solvent Selection
Item-specific solubility: Not specified for this item; refer to CoA/Spec Sheet.
General strategies for small-molecule assay stocks (literature/practice)
Primary solvent: anhydrous DMSO is the default for HTS/biochemical assays due to broad solvating power and aqueous miscibility at low percentages.
Secondary solvents: DMF and ethanol can aid dissolution for challenging chemotypes; test assay compatibility and final % v/v.
Aqueous dilution: after making a concentrated DMSO stock (e.g., 10–50 mM), dilute into assay buffer while vortexing to avoid local supersaturation. Maintain final DMSO typically 0.1–1% v/v.
Buffer modifiers: low levels of non-ionic surfactants (e.g., 0.01–0.05% Tween-20 or Pluronic F-68) can reduce aggregation; add only if validated for the assay.
pH leverage: if the compound is ionizable, dissolution may benefit from adjusting pH; confirm pKa/ionization to avoid degradation.
Water-sensitive chemotypes: if the structure contains hydrolytically labile motifs (esters, acid chlorides, lactols), prepare fresh stocks and minimize aqueous exposure. Structure for this item is not provided; apply general caution.
Comparison snapshot (general)
DMSO: highest success rate; potential assay interference at >1–2% v/v.
DMF: similar solvency; cytotoxic at modest %; handle with care.
Ethanol: greener, but less universal; can disrupt some protein assays.
Choose the least interfering solvent that achieves clear, stable solutions.
Storage and Reconstitution
Item-specific storage
Storage Conditions: Room temperature (as provided). Protect from moisture and excessive light as a general precaution.
Shipped In: Not specified for this item; refer to CoA/Spec Sheet.
General recommendations (not item-specific)
Solid form: Store tightly closed in a desiccator or with desiccant under inert atmosphere if possible. Record receipt date and batch/lot.
Solution stocks: For DMSO stocks, store at −20°C to −30°C in aliquots to avoid freeze–thaw cycling. Typical shelf life for discovery screening stocks is weeks to a few months, contingent on stability—verify by LC-MS/HPLC.
Reconstitution: If the compound is provided as a solid, prepare an initial DMSO stock (e.g., 10–50 mM). If aqueous stocks are required, evaluate solubility and stability at target pH and ionic strength before scale-up.
Adsorption/light sensitivity: Use amber vials if chromophoric; employ low-bind plastics to reduce loss at low micromolar concentrations.
Specifications not provided
Appearance, purity, water/peroxide/metal limits, and exact solubility: Not specified for this item; refer to CoA/Spec Sheet.
Always consult the SDS for safe handling during storage and reconstitution.
Structure and Identity
Item-specific facts (from Product Data)
Product Name: LY389795 (SKU: L611663)
CAS: L611663 (catalog placeholder; not a standard CAS Registry Number)
PubChem CID: 10058694
InChIKey: 292457 (as provided; format atypical for a standard InChIKey)
SMILES: Not specified for this item; refer to CoA/Spec Sheet.
Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.
General notes
Structural features (rings, heteroatoms, stereochemistry) and a 2D description cannot be summarized because no structure (SMILES/InChI) or formula has been provided in this listing. If you have a structure file (SDF/Mol), we can annotate functional groups, ring systems, and potential ionization sites.
If LY389795 corresponds to a known literature compound, please cross-check the identifiers on the Certificate of Analysis (CoA) or the PubChem record (CID 10058694) to confirm exact structure and stereochemistry prior to experimental use.
Synthetic Utility
Not typically applicable to this item
Without a disclosed structure or functional group profile, LY389795 should not be considered a general-purpose synthetic reagent or building block.
General comments (when structure is known)
If you later obtain the structure and it contains common handles (e.g., aryl halide, boronate, nitrile, amide, or heteroaryl groups), typical transformations might include cross-coupling, reductions/oxidations, or amide couplings. Such guidance must be based on verified structural data and should not be inferred from this listing.
Target Specificity
Item-specific data
Target/Pathway: Not specified for this item; refer to CoA/Spec Sheet or internal screening data.
Species reactivity, isotype/clone (for biologics), epitope: Not applicable to this small-molecule product.
Note
If LY389795 is used as a tool compound with a known target in your lab, document the assay conditions, EC50/IC50, and selectivity panel results locally; these are not provided in this product listing.
Need help choosing the grade?
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
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