Methocarbamol - Moligand™, 10mM in DMSO , Carbonic anhydrase I inhibitor, CAS No.532-03-6, Carbonic anhydrase I inhibitor

CAS: 532-03-6 Cat. No.: M408331 Molecular Weight: 241.24 EC Number: 208-524-3

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

AHR 85 | 3-​(2-​methoxyphenoxy)​-1,​2-​propanediol-1-​carbamate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Methocarbamol Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
In vitro

Methocarbamol is metabolized via dealkylation and hydroxylation followed by conjugation to form both glucuronides and sulfates.

In vivo

Methocarbamol results in a median terminal half-life, mean transit time, mean absorption time, and apparent oral clearance of 2.89 hours, 2.67 hours, 0.410 hours, and 16.5 mL/min/kg in the horse. Methocarbamol is rapidly absorbed and extensively metabolized after oral administration to horses as indicated by a short absorption time and modest systemic bioavailability of 54.4% in the horse. Methocarbamol is a centrally acting muscle relaxant available in both IV and oral forms in cats. Methocarbamol (100 mg/kg) does not change the heart rate, cardiac output, mean pulmonary arterial blood pressure, systolic, diastolic and mean aortic blood pressure, respiratory rate and arterial blood gases, but mild to moderate depression is observed in five of eight horses administered i.v. Methocarbamol, and in all horses administered oral Methocarbamol. Plasma Methocarbamol concentration declines very rapidly during the initial or rapid disposition phase after i.v. administration; the terminal elimination half-life ranged from 59 minutes to 90 minutes in horse. Peak plasma Methocarbamol concentrations following oral administration occur within 15 to 45 minutes in horse.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

AHR 85 | 3-​(2-​methoxyphenoxy)​-1, ​2-​propanediol-1-​carbamate

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Carbonic anhydrase I inhibitor

Names and Identifiers

• Isomeric SMILES: COC1=CC=CC=C1OCC(COC(=O)N)O
• RTECS: TY8750000
• Molecular Weight: 241.24
• Reaxy-Rn: 1884446
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1884446&ln=

Associated Targets(Human)

CA1 Tclin Carbonic anhydrase 1 (1 Activities)

Discover Target: CA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Melt Point(°C): 96°C