Methoxsalen - Moligand™, 10mM in DMSO , Agonist of TAS2R20, CAS No.298-81-7, Agonist of TAS2R20

CAS: 298-81-7 Cat. No.: M408757 Formula: C₁₂H₈O₄ Molecular Weight: 216.19 Beilstein Registry Number: 196453 EC Number: 206-066-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Xanthotoxin, NCI-C55903 | 9-methoxy-7H-furo[3,2-g]chromen-7-one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Methoxsalen (Xanthotoxin, NCI-C55903) is a naturally occurring photoactive substance found in the seeds of the Ammi majus (Umbelliferae) plant, used in the diagnosis and treatment of psoriasis; ACYP2A5/6inhibitor.
In vitro

Methoxsalen inhibits CYP2A6 (Ki = 0.8 μM) with about 3.5- 94-fold greater potency than other P450s, except for CYP1A2 (Ki = 0.2 μM). Methoxsalen shows noncompetitive inhibition of nicotine metabolism, with an apparent Ki value of 0.1 μM in cDNA-expressing microsomes. Methoxsalen is metabolized in human liver microsomes at the rate of 50-100 pmol/mg protein/min (approx. 30% of the activity in mouse liver microsomes). Methoxsalen is a very potent inhibitor of human cytochrome P450 2A6 (CYP2A6) and mouse Cyp2a-5-mediated coumarin 7-hydroxylation in vitro.

In vivo

Methoxsalen results in a significant decrease in the following factors: number and diameter of corpus lutei, Graafian follicles, diameter of granulosa cell layer and oocytes, number of primordial and primary and growing follicles, while the number of atretic follicle is increased. Methoxsalen also significantly reduces circulating estrogen levels in blood serum of oogenesis Balb/C mice. Methoxsalen dose-dependently stimulates a sustained increase in short-circuit current in the mouse jejunum. Methoxsalen increases the open probability of the basolateral IK(Ca) channel of isolated crypts in the mouse jejunum. Methoxsalen effectively reverses trimethyltin (TMT)-induced memory impairment on both Y-maze and passive avoidance tests in mice. Methoxsalen inhibits brain AchE activity. Methoxsalen significantly ameliorates the level of oxidative stress.
Cell Data

cell lines：D54 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Xanthotoxin, NCI-C55903 | 9-methoxy-7H-furo[3,2-g]chromen-7-one

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Methoxsalen (Xanthotoxin, NCI-C55903) is a naturally occurring photoactive substance found in the seeds of the Ammi majus (Umbelliferae) plant, used in the diagnosis and treatment of psoriasis; A CYP2A5/6 inhibitor.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of TAS2R20

Product Properties

• alogp: 1.9

Names and Identifiers

• Isomeric SMILES: COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2
• WGK Germany: 3
• RTECS: LV1400000
• Alternate CAS: 298-81-7
• NSC Number: 45923
• UN Number: 1759
• Packing Group: I
• MeSH Entry Terms: 8 Methoxypsoralen;8 MOP;8-Methoxypsoralen;8-MOP;8MOP;Ammoidin;Deltasoralen;Dermox;Geroxalen;M\u00e9ladinine;Meladinina;Meladinine;Meloxine;Methoxa Dome;Methoxa-Dome;Methoxsalen;Oxsoralen;Oxsoralen Ultra;Oxsoralen-Ultra;Puvalen;Ultramop;Xanthotoxin
• Molecular Weight: 216.19
• Beilstein: 196453
• Reaxy-Rn: 196453
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=196453&ln=

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (0 Activities)

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2A6 Tchem Cytochrome P450 2A6 (0 Activities)

Discover Target: CYP2A6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2A13 Tchem Cytochrome P450 2A13 (0 Activities)

Discover Target: CYP2A13

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACHE Tclin Acetylcholinesterase (0 Activities)

Discover Target: ACHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 57 mg/mL (199.81 mM); Ethanol: -1 mg/mL
• x_melt_point_char: 145℃-150℃

References

1. Fang Dong, Xin Chen, Xingyuan Men, Zhuo Li, Yujun Kong, Yiyang Yuan, Feng Ge.  (2023)  Contact Toxicity, Antifeedant Activity, and Oviposition Preference of Osthole against Agricultural Pests.  Insects,  14  (9): (725).  [PMID:37754693] [10.3390/insects14090725]

2. Sun Yujing, Wang Yihua, Zhang Le, Ye Xingqian, Guo Jingtong.  (2024)  Furanocoumarin profiles and inhibitory effects on cytochrome P450 activity of whole citrus fruit.  Food Quality and Safety,      [PMID:] [10.1093/fqsafe/fyae038]

3. Dandan Wang, Liangxiao Zhang, Yueqing Xu, Xin Qi, Xuefang Wang, Xiupin Wang, Qi Zhang, Peiwu Li.  (2019)  Optimization of an Ultrasound-Assisted Extraction for Simultaneous Determination of Antioxidants in Sesame with Response Surface Methodology.  Antioxidants,  8  (8): (321).  [PMID:31430991] [10.3390/antiox8080321]

4. Yingying Liu, Guowen Zhang, Ni Zeng, Song Hu.  (2016)  Interaction between 8-methoxypsoralen and trypsin: Monitoring by spectroscopic, chemometrics and molecular docking approaches.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:27653277] [10.1016/j.saa.2016.09.015]

5. Na Li, Xialian Cui, Yingjie Lu, Fang Zhang, Su Guo, Yue Su, Yinlong Guo.  (2025)  Spatial distribution analysis of secondary metabolites in bolted and unbolted Saposhnikovia divaricata by atmospheric pressure laser ablation carbon fiber ionization mass spectrometry imaging.  ANALYTICA CHIMICA ACTA,      [PMID:40374248] [10.1016/j.aca.2025.344096]

6. Deng Zhongyuan, Fang Liying, Cheng Lan, Yang Lihong, Zong Ruyi, Ding Qian, Wang Lixiang, Ni Xinzhi, Li Xianchun.  (2025)  Specialist/generalist divergence: phylogenetic constraints on the correlation between allelochemical tolerance spectra and host ranges of herbivorous insects.  JOURNAL OF PEST SCIENCE,  99  (1): (10).  [PMID:] [10.1007/s10340-025-02005-x]

7. Xinye Shi, Hang Su, Jing Tang, Yajing Zhang, Songtao Li, Yanhui Zhong, Zian Lin.  (2026)  Covalent organic framework-based solid-phase microextraction coupled with electrospray ionization mass spectrometry for in vivo determination of furanocoumarins in citrus fruits.  FOOD CHEMISTRY,      [PMID:41499891] [10.1016/j.foodchem.2025.147841]

Frequently Asked Questions

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 298-81-7, the molecular formula is C12H8O4, and the molecular weight is 216.19 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.