Methylthiouracil - 10mM in DMSO , CAS No.56-04-2

CAS: 56-04-2 Cat. No.: M408545 Formula: C₅H₆N₂OS Molecular Weight: 142.18 EC Number: 200-252-3

GRADE & PURITY 10mM in DMSO

Synonyms

NSC-193526, NSC-9378 | 6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Methylthiouracil (NSC-193526, NSC-9378) is an antithyroid agent. Methylthiouracil suppresses the productionTNF-αandIL-6, and the activation ofNF-κBandERK1/2.
In vitro

Methylthiouracil acts to decrease the formation of stored thyroid hormone, as thyroglobulin in the thyroid gland. Methylthiouracil is also used in combination with radioactive iodine.

In vivo

Cell Data

cell lines：MM1.S, MM.1R, LR5, RPMI 8226, DOX40, OPM1, OPM2, INA6, and U266

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

NSC-193526, NSC-9378 | 6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Methylthiouracil (NSC-193526, NSC-9378) is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

Isomeric SMILES

CC1=CC(=O)NC(=S)N1

UN Number

3077

Packing Group

III

Molecular Weight

142.18

Reaxy-Rn

115648

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=115648&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 64 mg/mL (199.17 mM); Water: Insoluble; Ethanol: Insoluble
• x_melt_point_char: 330°C