Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 9 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C ( PKC ) activity with an IC 50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti- orthopoxvirus activity with EC 50 s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively.
| pKa | pKa: 7.08 (Predicted), pKa: 9.27 (Predicted) |
|---|---|
| Ki Data | mAChR M2: Ki= 77.9 nM (human); mAChR M4: Ki= 89.8 nM (human); mAChR M1: Ki= 0.18 μM (human); SR-2C: Ki= 1.87 μM (human); HERG: Ki= 2.94 μM (human) |
| Isomeric SMILES | C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO |
|---|---|
| RTECS | CB5748500 |
| Molecular Weight | 444.48 |
| Beilstein | 2795126 |
| Reaxy-Rn | 2795126 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2795126&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Refractive Index | n20D1.71 |
|---|---|
| Boil Point(°C) | ~805.7° C at 760 mmHg (Predicted) |
| Melt Point(°C) | 170-174° C |
| 1. Zhi Li, Shuhua Han. (2022) A Chemosensor of 1,8-Dihydroxyanthraquinone PMOs Prepared in a Ternary Deep Eutectic Solvent for the Sensitive Detection of Cu2+. ACS Omega, [PMID:35811913] [10.1021/acsomega.2c01944] |
| 2. Chunli Lou, Xiongzhen Ye, Ge Chen, Jidong Zhu, Jingwu Kang. (2020) Screening inhibitors for blocking UHRF1-methylated DNA interaction with capillary electrophoresis. JOURNAL OF CHROMATOGRAPHY A, [PMID:33340746] [10.1016/j.chroma.2020.461790] |
| 3. Tao Xiaojun, Tao Ting, Wen Yi, Yi Jiajin, He Lihua, Huang Zixuan, Nie Yu, Yao Xiaoyan, Wang Yingying, He Chunlian, Yang Xiaoping. (2018) Novel Delivery of Mitoxantrone with Hydrophobically Modified Pullulan Nanoparticles to Inhibit Bladder Cancer Cell and the Effect of Nano-drug Size on Inhibition Efficiency. Nanoscale Research Letters, 13 (1): (1-12). [PMID:30377872] [10.1186/s11671-018-2769-x] |
| 4. Qianyu Xu, Haoyang Fu, Jiyuan Gu, Liyu Lei, Lan Ling. (2024) Catalytic detoxification of mitoxantrone by graphitic carbon nitride (g-C3N4) supported Fe/Pd bimetallic nanoparticles. Journal of Environmental Sciences, [PMID:39095194] [10.1016/j.jes.2024.01.044] |
| 5. Tao Yanru, Zhao Hua, Xiang Yujie, Li Jin, Li Yanting, Hu Jiangling, Wang Hongmei, Jiang Xinhui. (2024) Development and Validation of a New High-Performance Liquid Chromatography-Ultraviolet Assay for Quantification of Mitoxantrone in Plasma of BALB/c-nu Mice. JOURNAL OF CHROMATOGRAPHIC SCIENCE, [PMID:38493310] [10.1093/chromsci/bmae007] |
| 6. Yixuan Zhao, Jiahui Zhao, Shuqin Liu, Dunqing Wang, Jian Liu, Fei Zhang, Xiangshu Chen. (2024) Melamine enhancing Cu-Fenton reaction for degradation of anthracyclines. JOURNAL OF HAZARDOUS MATERIALS, [PMID:39362119] [10.1016/j.jhazmat.2024.136035] |
| 7. Haiying Liu, Yuqi Liu, Xiaoxi Lin, Jianhui Fan, Zhao Huang, Ao Li. (2024) Mitoxantrone attenuates lipopolysaccharide-induced acute lung injury via inhibition of NEDD8 activating enzyme. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:39541844] [10.1016/j.intimp.2024.113605] |
| 8. Hongjie Zhang, Rui Geng, Benyan Zheng, Jing Wang, Yuan Hu, Xiaopeng Ma. (2025) Ultrasound-Enhanced Mitochondrial Targeting for Synergistic Mitoxantrone-Based Nanotherapy in Triple-Negative Breast Cancer. ACS Applied Nano Materials, [PMID:] [10.1021/acsanm.4c06594] |
| 9. Chang Liu, Zhilin Hao, Ziming Wang, Kun Cui, Chen Zhang, Jingrong Wang, Lulu Guo, Fuqiang Liu, Qixin Deng, Zi Yang, Xudong Chen, Maojun Yang, Jianping Xie, Sensen Zhang, Jian Mao. (2026) Structure of the Insect Alkaline Taste Receptor Alka and Insights into Its Alkaline Ligand Recognition Mechanism. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:41601143] [10.1021/acs.jafc.5c13948] |
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