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MK-0249 - ≥99% , CAS No.M658788
AVAILABLE TO ORDER
GRADE & PURITY ≥99%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
MK-0249 (Compound 1) is a potent, selective and orally active histamine H 3 receptor antagonist, with an IC 50 of 1.7 nM for human H3.
IC50& Target:human H 3 receptor 1.7 nM (IC 50 ) rhesus H 3 receptor 4.3 nM (Ki) human H 3 receptor 6.8 nM (Ki) rat H 3 receptor 33 nM (Ki)
In Vitro:MK-0249 (Compound 1) shows very good hepatic clearance values (CLh e 11 mL/min/kg), and is a substrate for rat P-gp but not for human P-gp. MK-0249 displays potent binding affinity to human, rat, and rhesus H 3 receptors with K i values of 6.8 ± 1.3
Biological Activity:MK-0249 (Compound 1) is a potent, selective and orally active histamine H 3 receptor antagonist, with an IC 50 of 1.7 nM for human H3.
Specifications
Specifications & Purity
≥99%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
ANTAGONIST
Purity
≥99%
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Solution Calculators
Reviews
Customer Reviews
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