NS309 - Moligand™, ≥98%(HPLC) , Activator of K Ca2.1;Activator of K Ca2.2;Activator of K Ca2.3;Activator of K Ca3.1, CAS No.18711-16-5, Activator of K Ca2.1;Activator of K Ca2.2;Activator of K Ca2.3;Activator of K Ca3.1

CAS: 18711-16-5 Cat. No.: N126635 Molecular Weight: 231.04 EC Number: 633-759-7 PubChem CID: 135502903

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

AKOS024457856 | F84856 | NS309 | NS-309 | AKOS025248274 | NS309, >=98% (HPLC), solid | (e)-6,7-dichloro-3-(hydroxyimino)indolin-2-one | 2-(aminomethyl)-4-(7-chloroquinolin-4-ylamino)phenol;NS-309 | 3-Oxime-6,7-dichloro-1H-indole-2,3-dione | (Z)-6,7-dichlo

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

NS309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.
A Ca2+-activated IK/SK potassium channel activator

Specifications

Synonyms

AKOS024457856 | F84856 | NS309 | NS-309 | AKOS025248274 | NS309, >=98% (HPLC), solid | (e)-6, 7-dichloro-3-(hydroxyimino)indolin-2-one | 2-(aminomethyl)-4-(7-chloroquinolin-4-ylamino)phenol;NS-309 | 3-Oxime-6, 7-dichloro-1H-indole-2, 3-dione | (Z)-6, 7-dichlo

Specifications & Purity

Moligand™, ≥98%(HPLC)

Biochemical and Physiological Mechanisms

Potent activator of human Ca 2+ -activated K + channels of SK and IK types, selective over BK type channels (EC 50 = 10 nM for increasing hIK current). At least 1000 times more potent than 1-EBIO .

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ACTIVATOR

Mechanism of action

Activator of K Ca2.1;Activator of K Ca2.2;Activator of K Ca2.3;Activator of K Ca3.1

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 488202954
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488202954
• Canonical Smiles: C1=CC(=C(C2=C1C(=C(N2)O)N=O)Cl)Cl
• IUPAC Name: 6,7-dichloro-3-nitroso-1H-indol-2-ol
• InChIKey: ROBYKNONIPZMTK-UHFFFAOYSA-N
• INCHI: 1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,11,13H
• Isomeric SMILES: C1=CC(=C(C2=C1C(=C(N2)O)N=O)Cl)Cl
• WGK Germany: 2
• PubChem CID: 135502903
• Molecular Weight: 231.04

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Indoles and derivatives
      • Subclass Hydroxyindoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Indoles and derivatives
• Subclass: Hydroxyindoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Hydroxyindoles
• Alternative Parents: Indoles Substituted pyrroles Benzenoids Aryl chlorides Heteroaromatic compounds Propargyl-type 1,3-dipolar organic compounds C-nitroso compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organochlorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Hydroxyindole - Indole - Benzenoid - Substituted pyrrole - Aryl halide - Aryl chloride - Heteroaromatic compound - Pyrrole - Organic nitroso compound - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - C-nitroso compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as hydroxyindoles. These are organic compounds containing an indole moiety that carries a hydroxyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

KCNN4 Tchem Intermediate conductance calcium-activated potassium channel protein 4 (1 Activities)

Discover Target: KCNN4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN1 Tchem Small conductance calcium-activated potassium channel protein 1 (0 Activities)

Discover Target: KCNN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN3 Tchem Small conductance calcium-activated potassium channel protein 3 (0 Activities)

Discover Target: KCNN3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN2 Tchem Small conductance calcium-activated potassium channel protein 2 (1 Activities)

Discover Target: KCNN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: DMSO
• Sensitivity: Air sensitive
• Molecular Weight: 231.030 g/mol
• XLogP3: 3.200
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 229.965 Da
• Monoisotopic Mass: 229.965 Da
• Topological Polar Surface Area: 65.500 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 241.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1