ONO-3805 , CAS No.119347-91-0

CAS: 119347-91-0 Cat. No.: O1440102 Formula: C₃₁H₃₆NNaO₅ Molecular Weight: 525.61

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

ONO-3805 is an early lead compound of a non-steroidal 5α-reductase inhibitor, used to inhibit the conversion of testosterone to dihydrotestosterone, with potential effects in inhibiting benign prostatic hyperplasia.

Specifications

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

Molecular Weight

525.61

Application Protocols

No tested application protocols are provided in the Product Data for ONO-3805.

General usage guidance for small-molecule research compounds (not item-specific):

• Stock solution: Dissolve an accurately weighed amount in dry DMSO to a convenient concentration (e.g., 10–50 mM), vortex and sonicate if needed. Record exact concentration and date.
• Aliquoting: Dispense into single-use vials or plates under dry, inert conditions if the compound is moisture/air sensitive (status unknown for this item), then store at −20°C as specified.
• Working solutions: Dilute into assay buffer or media to the desired final concentration, controlling final DMSO at assay-validated levels.
• Documentation: Note batch/lot, storage history, and any observed precipitation or color change.

For analytical protocols (HPLC/LC–MS):

• Use LC–MS grade solvents and 0.22 µm filtration. Begin with a generic gradient (e.g., water + 0.1% formic acid / acetonitrile + 0.1% formic acid) and adjust based on observed retention and ionization once the structure is known.

Biological Roles

Target class, mechanism, or biological role for ONO-3805 is not provided in the Product Data. Without a confirmed structure or target annotation, no item-specific biological function can be stated.

General considerations for small-molecule research compounds (literature-style guidance, not item-specific):

• Tool compounds are employed to perturb specific biochemical pathways, enabling target validation, pathway mapping, and phenotypic screening. Confirm target specificity and off-target profiles from primary literature and the CoA before interpreting biological results.
• Stock handling influences biological data quality: ensure accurate concentration (weigh by analytical balance), avoid adsorption losses (use low-bind plastics or glass), and limit DMSO to assay-tolerated levels.
• If transporter permeability or metabolic stability are relevant, consider parallel experiments (microsomal stability, plasma protein binding, Caco-2/MDCK permeability) using standard protocols.

Note: ONO-3805 is supplied strictly for research use only. No clinical, diagnostic, or in vivo human/animal use is implied or authorized by this listing.

Buffer Applications

Buffer formulation guidance is typically applicable to buffer reagents, not to generic small-molecule library members. For ONO-3805, no buffer-specific role is provided in the Product Data.

Practical notes when incorporating small molecules into buffered systems (general guidance):

• Prepare concentrated stocks in a miscible organic solvent (often DMSO), then dilute into the working buffer to the desired final concentration, keeping organic co-solvent ≤0.1–1% v/v where possible.
• Filter final assay solutions through 0.22 µm membranes to remove particulates. Confirm that the compound remains in solution at working temperature and ionic strength.
• Avoid extreme pH unless the compound’s ionization profile (pKa) is known from the CoA or literature.

Green Alternatives

Green chemistry considerations can be applied to handling and use even when compound-specific data are limited.

Solvent choices (general guidance, not item-specific):

• Prefer greener dissolution solvents for preparative work when compatible with the compound and end-use:
  • 2-Methyltetrahydrofuran (2-MeTHF) and cyclopentyl methyl ether (CPME) as alternatives to THF/Et2O in synthesis/extractions.
  • Ethyl acetate or dimethyl carbonate as alternatives to chlorinated solvents for workups.
  • Bio-based ethanol or isopropanol for cleaning and low-polarity dilutions.
• For analytical/bioassay stocks, dry DMSO remains common; consider propylene carbonate or PEG-400 for certain nonaqueous applications, balancing viscosity and assay compatibility.

Tradeoffs to note:

• 2-MeTHF/CPME offer lower peroxide formation rates and better safety profiles than diethyl ether/THF but can alter reaction kinetics and selectivity.
• Ethyl acetate is greener than dichloromethane but may be less effective for highly nonpolar solutes.
• Propylene carbonate is low volatility and greener than DMF/DMAC but can be too polar or incompatible with some assays.

Operational tips:

• Minimize solvent volumes through higher-concentration stocks and accurate microdosing.
• Capture/segregate solvent waste by class to enable appropriate recycling or disposal.

Pharmaceutical Uses

No pharmacopeial status, excipient role, or formulation usage is specified for ONO-3805 in the Product Data. This product is supplied for research use only and is not intended for human or veterinary use.

General, non–item-specific considerations for formulation research with small molecules:

• Solubility enhancement strategies (preclinical research): co-solvent systems, pH adjustment (if ionizable), cyclodextrin inclusion, or lipid-based vehicles. Select methods only after structure and ionization are known from the CoA.
• Analytical control: Develop stability-indicating methods (e.g., LC–UV/LC–MS) to monitor degradation under light, heat, and oxidative stress as part of preformulation studies.
• Excipients: Choose pharmaceutically acceptable excipients only for research simulations; ensure compatibility and avoid reactive excipients if functional groups are unknown.

No therapeutic or clinical claims are made or implied for this product.

Physical Properties

Item-specific physicochemical properties are not provided in the Product Data for ONO-3805.

Not specified for this item; refer to CoA/Spec Sheet for the following:

• Appearance (solid/oil/color): Not specified.
• Melting point (MP): Not specified.
• Boiling point (BP): Not specified.
• Density: Not specified.
• Refractive index: Not applicable if solid; otherwise not specified.
• Solubility profile (water/organic solvents): Not specified.
• logP/logD, pKa: Not specified.

General laboratory guidance (literature-style, not item-specific):

• For unknown small molecules, initial dissolution trials typically start with dry DMSO (10–50 mg/mL), followed by serial dilution into assay buffers containing co-solvent (≤1% v/v DMSO) if biological testing is planned.
• If crystallinity suggests limited solubility, consider co-solvents (DMF, ethanol) or gentle warming/sonication during stock preparation. Always filter through 0.22 µm PTFE for analytical use.
• If hygroscopicity or polymorphism is suspected, handle quickly at ambient conditions and store desiccated at the specified temperature (see Storage & Reconstitution).

Quality and Grades

Grade/purity for this specific ONO-3805 listing is not provided in the Product Data.

Item-specific notes:

• Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet for assay purity, related substances, and residual solvents.

General guidance on grades (context for small-molecule research compounds):

• Research grade: Suitable for discovery research, screening, and method development; typical documentation includes HPLC/UPLC purity (area %), and LC–MS/HRMS confirmation.
• HPLC/LC–MS reference standard grade: Emphasizes high purity and complete analytical characterization (NMR, HRMS), low volatile/UV-absorbing impurities; use when quantitative analysis demands traceable standards.
• Stabilizers: If an inhibitor of oxidation or acid scavenger is used, it will be declared on the CoA. Absence of any stabilizer should also be indicated. For this item, stabilizer content is not specified.

What to check on receipt:

• Review CoA for purity method (e.g., 254 nm vs. multi-wavelength), residual solvent limits, water content (KF), and batch-specific appearance.
• If using in bioassays, verify endotoxin/bioburden expectations (rarely provided for small molecules unless specified).

Reaction and Applications

No specific synthetic or application notes are provided for ONO-3805 in the Product Data. In our catalog, compounds in the small-molecule library are commonly used as:

• Reference materials or tool compounds in target validation and screening campaigns (when target relevance is known from literature—obtain from CoA or primary sources).
• Analytical standards for method development (e.g., LC–MS retention mapping), stability studies, and recovery experiments.
• Controls in SAR studies when related analogs are under evaluation.

General, non–item-specific recommendations:

• If using as a screening hit/control, prepare single-use aliquots to avoid freeze–thaw cycling and concentration drift.
• For analytical development, create calibration curves from independently weighed stock solutions; confirm purity by orthogonal methods (e.g., HPLC-UV and LC–MS) when accuracy is critical.
• If chemical reactivity is unknown, avoid strong bases/nucleophiles and oxidants until structural information is confirmed from the CoA or literature.

If you intend to use ONO-3805 as a synthetic building block, obtain the full structure from the CoA to assess functional group compatibility and choose conditions accordingly (e.g., moisture sensitivity, protecting group strategies).

Reaction Conditions

No reaction conditions are specified for ONO-3805. Without structural information, recommended temperatures, catalysts, or solvents for transformations cannot be provided.

General notes (literature-style, not item-specific):

• If derivatization is contemplated, start with mild conditions and small-scale scouting. Use orthogonal analytical readouts (TLC, LC–MS, NMR) to monitor conversion and degradation.
• For purification, select methods aligned with polarity and stability: flash chromatography with gradient elution, or preparative HPLC for higher purity needs.
• Thermal stability and photostability should be assessed empirically once the structure and chromophores are known.

For any specific transformation, consult primary literature after confirming ONO-3805’s structure from the CoA.

Safety and Handling

Hazard classification for this specific item is not provided in the Product Data. Always consult the product SDS for authoritative safety information prior to use.

Item-specific hazard fields:

• Signal Word: Not specified for this item; refer to SDS.
• H-Statements: Not specified for this item; refer to SDS.
• GHS Classification: Not specified for this item; refer to SDS.
• Pictograms: Not specified for this item; refer to SDS.

General laboratory safety (good practice for small organic molecules):

• PPE: Wear lab coat, safety glasses or goggles, and appropriate chemically resistant gloves (e.g., nitrile). Avoid skin/eye contact and inhalation of dust or vapors.
• Engineering controls: Handle powders/solids in a fume hood; minimize aerosolization. Use closed containers and secondary containment during weighing and transfers.
• Incompatibilities: Unknown for this item; as a precaution, segregate from oxidizers, strong acids/bases, and ignition sources until specific data are known.
• First aid (overview; follow SDS/site protocol): In case of skin contact, wash with soap and water; eye contact, flush with water for ≥15 minutes; inhalation, move to fresh air; ingestion, rinse mouth—seek medical attention for all exposures.
• Spill response: Avoid dust, collect with inert absorbent, place in suitable waste container, and ventilate area.
• Waste: Dispose via hazardous chemical waste stream per institutional and local regulations.

Solvent Selection

Solubility and polarity data for ONO-3805 are not specified for this item. Below is general, literature-style guidance for dissolving unknown small molecules for research use.

Practical starting points:

• Stock preparation: Dry DMSO is the default solvent for many screening compounds. Begin at 10–50 mg/mL, then dilute into aqueous buffers keeping final DMSO ≤0.1–1% v/v as assay permits.
• Alternative organic solvents: If DMSO is unsuitable, trial DMF, acetonitrile, ethanol, or isopropanol. For very nonpolar compounds, try ethyl acetate, MTBE, or toluene for synthetic work (not for bioassay dilution).
• Aqueous solubility: If required, consider pH adjustment only when ionizable groups are known from the CoA/structure. Without pKa, avoid extreme pH.

Small comparison (general guidance, not item-specific):

• DMSO: Broad solvency, high boiling point, miscible with water; may interfere with certain assays at >1%.
• DMF: Strong solvent, miscible with water; handle with care due to toxicity concerns.
• Ethanol: Biologically compatible at low %; limited solvency for very lipophilic molecules.
• Acetonitrile: Good for analytical dilutions; limited water miscibility impacts high-concentration stocks.

Tips:

• Filter organic solutions through PTFE membranes. For aqueous dilutions containing DMSO, use PVDF or PES filters.
• Record exact solvent lot and concentration on vials for reproducibility.

Storage and Reconstitution

Storage specifics from Product Data:

• Storage Conditions: Store at −20°C.
• Shipped In: Ice chest + ice pads.
• Research Use Note: For research use only.

Item-specific details not provided:

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Stabilizers/antioxidants: Not specified for this item; refer to CoA/Spec Sheet.

General best practices for small-molecule storage and reconstitution (not item-specific):

• Upon receipt: Allow the sealed container to equilibrate to room temperature before opening to minimize condensation. Open in a low-humidity environment.
• Primary storage: Keep tightly closed under dry, inert atmosphere (if available) at −20°C. Use desiccant and light-protective secondary containment if the compound is light/moisture sensitive (status unknown for this item).
• Aliquoting: Prepare single-use aliquots of solid or concentrated stock (e.g., 10–50 mM in dry DMSO). Avoid repeated freeze–thaw cycles.
• Reconstitution: Dissolve with gentle vortexing and short sonication in a suitable solvent. If particles persist, warm slightly (≤40°C) and/or filter through 0.22 µm PTFE (organic) or PVDF (aqueous/DMSO mixtures).
• Stability: Absent item-specific stability data, plan to use reconstituted solutions within a few days refrigerated and store long-term stocks at −20°C or below.
• Documentation: Record date of opening, solvent, concentration, and any observations (color/precipitation) on the container and in electronic records.

Structure and Identity

ONO-3805 is listed as a small-molecule research compound in our small-molecule and compound library category.

Item-specific identifiers (from Product Data):

• SKU: O1440102
• Product Name: ONO-3805
• CAS: 119347-91-0
• Category Path: 全部 / 可售 / 小分子和化合物库

Chemical identity details for this item:

• Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• InChIKey: Not specified for this item; refer to CoA/Spec Sheet.

Structural features (general guidance):

• Without a provided structure, functional groups, ring systems, and stereochemistry cannot be confirmed for this item. Consult the CoA/Spec Sheet or SDS for definitive structural descriptors.

How to reference/track identity in the lab:

• Use the CAS number 119347-91-0 and SKU O1440102 on all documentation and labels.
• If analytical confirmation is required, obtain the structure from the CoA, then verify by NMR/HRMS/HPLC as appropriate (general recommendation).

Synthetic Utility

The synthetic utility of ONO-3805 cannot be described without its disclosed structure. No functional groups or reactivity patterns are provided in the Product Data.

General strategic guidance (not item-specific):

• If the compound is intended as a building block or intermediate, obtain the structural data from the CoA, then assess:
  • Functional handles (e.g., halides, boronates, carboxylic acids, amines) for cross-coupling, amidation, or nucleophilic substitutions.
  • Chemoselectivity risks and protection strategies if multiple reactive sites are present.
  • Stability toward acids/bases, redox conditions, and heat to set reaction windows.
• For library expansion, consider analog generation via late-stage diversification (e.g., C–H functionalization, photoredox couplings) once core functionality is known.

Until the structure is confirmed, treat ONO-3805 as a finished research compound rather than a synthetic starting material.

Target Specificity

Target, mechanism, and selectivity data are not provided for ONO-3805 in the Product Data.

Item-specific fields:

• Target/Pathway: Not specified for this item; refer to CoA/Spec Sheet or primary literature.
• Potency/Selectivity metrics: Not specified for this item; refer to CoA/Spec Sheet.

General guidance for researchers:

• Verify the intended biological target from authoritative sources and cross-check assay conditions (substrates, cofactors, cell lines) before use as a reference tool compound.
• Incorporate orthogonal assays and counter-screens to evaluate off-target activity and assay interference (e.g., fluorescence quenching, redox cycling) when the compound’s structure is known.

Frequently Asked Questions

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 119347-91-0, the molecular formula is C31H36NNaO5, and the molecular weight is 525.61 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.