OSMI-4 - ≥97% , CAS No.2260791-14-6

CAS: 2260791-14-6 Cat. No.: O414263 Molecular Weight: 604.09 PubChem CID: 137319721

GRADE & PURITY ≥97%

Synonyms

ethyl (R)-N-(2-((7-chloro-2-oxo-1,2-dihydroquinoline)-6-sulfonamido)-2-(2-methoxyphenyl)acetyl)-N-(thiophen-2-ylmethyl)glycinate

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Information

OSMI-4 OSMI-4 is an inhibitor of O-GlcNAc transferase (OGT) with EC50 of 3 μM in cells.

Targets

OGT (Cell-free assay) 3 μM(EC50)

In vitro

OSMI-4 reduces O-GlcNAc levels almost completely by 5 μM. A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 is observed in cells treated with OSMI-4. OSMI-4 is a kind of structure-based evolution of small molecule OGT inhibitors with low nanomolar binding affinities. OSMI-4 exhibits a ~3 μM EC50 in cells, making it especially attractive for probing OGT’s complex biology.

Cell Research(from reference)

Cell lines：HEK293T cells 

Concentrations：5 μM, 10 μM, 20 μM 

Incubation Time：2 h, 8 h, 16 h, 24 h 

Specifications

Synonyms

ethyl (R)-N-(2-((7-chloro-2-oxo-1, 2-dihydroquinoline)-6-sulfonamido)-2-(2-methoxyphenyl)acetyl)-N-(thiophen-2-ylmethyl)glycinate

Specifications & Purity

≥97%

Biochemical and Physiological Mechanisms

OSMI-4 is an inhibitor of O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) with EC50 of 3 μM in cells.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥97%

Product Properties

• ALogP: 3.175
• HBD Count: 2
• Rotatable Bond: 12

Names and Identifiers

• Pubchem Sid: 504773493
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773493
• Canonical Smiles: CCOC(=O)CN(CC1=CC=CS1)C(=O)C(C2=CC=CC=C2OC)NS(=O)(=O)C3=C(C=C4C(=C3)C=CC(=O)N4)Cl
• IUPAC Name: ethyl 2-[[(2R)-2-[(7-chloro-2-oxo-1H-quinolin-6-yl)sulfonylamino]-2-(2-methoxyphenyl)acetyl]-(thiophen-2-ylmethyl)amino]acetate
• InChIKey: STPSLAZMEWZDAJ-AREMUKBSSA-N
• INCHI: 1S/C27H26ClN3O7S2/c1-3-38-25(33)16-31(15-18-7-6-12-39-18)27(34)26(19-8-4-5-9-22(19)37-2)30-40(35,36)23-13-17-10-11-24(32)29-21(17)14-20(23)28/h4-14,26,30H,3,15-16H2,1-2H3,(H,29,32)/t26-/m1/s1
• PubChem CID: 137319721
• Molecular Weight: 604.09

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 100 mg/mL (165.53 mM); Water: Insoluble; Ethanol: Insoluble
• DMSO(mg / mL) Max Solubility: 100
• DMSO(mM) Max Solubility: 165.538247612111
• Water(mg / mL) Max Solubility: ＜1