p53 Activator 7 - ≥98% , CAS No.2849340-59-4

CAS: 2849340-59-4 Cat. No.: P646987 Molecular Weight: 516.54

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Overview

p53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC 50 of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1)

In Vitro

The p53 protein, referred to as the “guardian of the human genome” , is a tetrameric transcription factor that prevents mutation to the genome by regulating the expression of a subgroup of target genes. Although biologically active as a homotetramer, each p53 monomer is comprised of 393 amino acids, and is divided into five key regulatory domains: the transactivation domain (TAD) , proline-rich region (PR) , the DNA binding domain (DBD) , the oligomerization domain (OD) , and the C-terminus. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:EC50: 104 nM (p53 mutation Y220C)

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

p53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC 50 of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1).

Storage

Store at 2-8°C, Protected from light, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: FC(F)(F)CN1C2=C(C(NC3CCN(CC3)C)=CC=C2)C=C1C#CCNC4=CC=C(P(C)(C)=O)C=C4
• Molecular Weight: 516.54

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (193.60 mM; Need ultrasonic)