p53 Activator 7 - ≥98% , CAS No.2849340-59-4

CAS: 2849340-59-4 Cat. No.: P646987 Formula: C₂₇H₃₂F₃N₄OP Molecular Weight: 516.54

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Overview

p53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC 50 of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1)

In Vitro

The p53 protein, referred to as the “guardian of the human genome” , is a tetrameric transcription factor that prevents mutation to the genome by regulating the expression of a subgroup of target genes. Although biologically active as a homotetramer, each p53 monomer is comprised of 393 amino acids, and is divided into five key regulatory domains: the transactivation domain (TAD) , proline-rich region (PR) , the DNA binding domain (DBD) , the oligomerization domain (OD) , and the C-terminus. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:EC50: 104 nM (p53 mutation Y220C)

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

p53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC 50 of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1).

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: FC(F)(F)CN1C2=C(C(NC3CCN(CC3)C)=CC=C2)C=C1C#CCNC4=CC=C(P(C)(C)=O)C=C4
• Molecular Weight: 516.54

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (193.60 mM; Need ultrasonic)

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2849340-59-4, the molecular formula is C27H32F3N4OP, and the molecular weight is 516.54 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.