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· · COA & SDS available for every product · Same-day shipping on in-stock items PF-8380 - Moligand™, 10mM in DMSO , Inhibitor of autotaxin, CAS No.1144035-53-9, Inhibitor of autotaxin
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO Synonyms
HMS3740G07 | 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester | CCG-269523 | 3,5-Dichlorobenzyl-[4-[3-oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]]piperazine-1-carboxylate | 1-Piperazinecarboxyli
Shipped In
Dry ice packs + Cold packs
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Why this grade Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview PF-8380 is a potent and specific autotaxin inhibitor with an IC50 value of 2.8 nM.
Specifications Synonyms
HMS3740G07 | 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester | CCG-269523 | 3,5-Dichlorobenzyl-[4-[3-oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]]piperazine-1-carboxylate | 1-Piperazinecarboxyli
Specifications & Purity
Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms
PF-8380 is an orally bioavailable piperazinylbenzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50 = 2.8 and 1.7 nM for recombinant human enzyme-β isoform employing FS-3 and LPC (lysophosphatid
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Inhibitor of autotaxin
Names and Identifiers Pubchem Sid 528766623 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/528766623 Canonical Smiles C1CN(CCN1CCC(=O)C2=CC3=C(C=C2)NC(=O)O3)C(=O)OCC4=CC(=CC(=C4)Cl)Cl IUPAC Name (3,5-dichlorophenyl)methyl 4-[3-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)propyl]piperazine-1-carboxylate InChIKey JMSUDQYHPSNBSN-UHFFFAOYSA-N INCHI 1S/C22H21Cl2N3O5/c23-16-9-14(10-17(24)12-16)13-31-22(30)27-7-5-26(6-8-27)4-3-19(28)15-1-2-18-20(11-15)32-21(29)25-18/h1-2,9-12H,3-8,13H2,(H,25,29) Isomeric SMILES C1CN(CCN1CCC(=O)C2=CC3=C(C=C2)NC(=O)O3)C(=O)OCC4=CC(=CC(=C4)Cl)Cl WGK Germany 3 Molecular Weight 478.33 Reaxy-Rn 20608196 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20608196&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Benzoxazoles Subclass Benzoxazolones Intermediate Tree Nodes Not available Direct Parent Benzoxazolones Alternative Parents Benzyloxycarbonyls Piperazine carboxylic acids Aryl alkyl ketones Dichlorobenzenes N-alkylpiperazines Aryl chlorides Beta-amino ketones Oxazoles Heteroaromatic compounds Carbamate esters Trialkylamines Oxacyclic compounds Azacyclic compounds Organochlorides Organic oxides Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents Benzyloxycarbonyl - Benzoxazolone - Piperazine-1-carboxylic acid - 1,3-dichlorobenzene - Aryl alkyl ketone - Aryl ketone - Chlorobenzene - Halobenzene - N-alkylpiperazine - Beta-aminoketone - Aryl chloride - Aryl halide - Piperazine - Benzenoid - 1,4-diazinane - Monocyclic benzene moiety - Heteroaromatic compound - Carbamic acid ester - Oxazole - Azole - Tertiary aliphatic amine - Ketone - Tertiary amine - Azacycle - Oxacycle - Amine - Organohalogen compound - Carbonyl group - Organochloride - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as benzoxazolones. These are organic compounds containing a benzene fused to an oxazole ring (a five-member aliphatic ring with three carbon atoms, one oxygen atom, and one nitrogen atom) bearing a ketone group. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Molecular Weight 478.300 g/mol XLogP3 3.200 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 7 Exact Mass 477.086 Da Monoisotopic Mass 477.086 Da Topological Polar Surface Area 88.200 Ų Heavy Atom Count 32 Formal Charge 0 Complexity 693.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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