PF-9366 - 10mM in DMSO , CAS No.72882-78-1

CAS: 72882-78-1 Cat. No.: P425692 Formula: C₂OH₁₉ClN₄ Molecular Weight: 350.84 PubChem CID: 12612431

GRADE & PURITY 10mM in DMSO

Synonyms

[1,​2,​4]​Triazolo[4,​3-​a]​quinoline-​1-​ethanamine,7-​chloro-​N,​N-​dimethyl-​5-​phenyl-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

PF-9366 PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor with IC50 of 420 nM and Kd of 170 nM.

Targets

hMat2A (Cell-free assay); hMat2A (Cell-free assay) 170 nM(Kd); 420 nM

Specifications

Synonyms

[1,​2,​4]​Triazolo[4,​3-​a]​quinoline-​1-​ethanamine,7-​chloro-​N,​N-​dimethyl-​5-​phenyl-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor with IC50 of 420 nM and Kd of 170 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Product Properties

• alogp: 4.355
• hba_count: 2
• rotatable_bond: 4

Names and Identifiers

• Isomeric SMILES: CN(C)CCC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=C2)C4=CC=CC=C4
• PubChem CID: 12612431
• Molecular Weight: 350.84

Associated Targets(Human)

MAT2A Tchem S-adenosylmethionine synthase isoform type-2 (713 Activities)

Discover Target: MAT2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• dmso_mg_max_solubility: 15
• dmso_mM_max_solubility: 42.7545319803899
• water_mg_max_solubility: ˂1

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 72882-78-1, the molecular formula is C20H19ClN4, and the molecular weight is 350.84 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.