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Bioactive Small Molecules
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Metabolic Enzyme/Protease
Aldose Reductase
Ponalrestat - Moligand™, 10 mM in DMSO , CAS No.72702-95-5

Ponalrestat - Moligand™, 10 mM in DMSO , CAS No.72702-95-5

Name: Ponalrestat - Moligand™, 10 mM in DMSO , CAS No.72702-95-5
SKU: P1493876
Availability: InStock

CAS: 72702-95-5 Cat. No.: P1493876 Formula: C₁₇H₁₂BrFN₂O₃ Molecular Weight: 391.2 PubChem CID: 5278

COA

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Ponalrestat - Moligand™, 10 mM in DMSO CAS No(72702-95-5) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY Moligand™ ? 10 mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview Specifications Product Properties Names and Identifiers Documentation Advanced Data Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties FAQs and Articles Solution Calculators Reviews

🧪

Why this grade

Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Desiccated,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 ( K i =7.7 nM) over ALR1 ( K i =60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Product Properties

pKa	pKₐ: 3.36 (Predicted)

Names and Identifiers

Isomeric SMILES	C1=CC=C2C(=C1)C(=NN(C2=O)CC3=C(C=C(C=C3)Br)F)CC(=O)O
PubChem CID	5278
Molecular Weight	391.2

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

x_refractive_index	n20D1.66 (Predicted)
x_boil_point_char	576.33° C at 760 mmHg (Predicted)
x_melt_point_char	224.29° C (Predicted)

FAQs and Articles

1,8-Naphthyridine-Based Aldose Reductase Inhibitors: Scaffold Construction, In Vitro Inhibitory Activity, and Directions for Structural Optimization

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

1,8-naphthyridine aldose reductase ALR2 AKR1B1 aldose reductase inhibitor pharmacophore benzylic bromination

Solution Calculators

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Reviews

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Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.

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