≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C,Protected from light,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 20 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
PPA is an ADC linker (US20060073528A1). PPA can be used for making antibody-drug conjugate
Form:Solid
IC50& Target:Disulfide Cleavable
| Canonical Smiles | CC(CCC(=O)O)SSC1=CC=CC=N1 |
|---|---|
| IUPAC Name | 4-(pyridin-2-yldisulfanyl)pentanoic acid |
| InChIKey | OOUPHXWHXYLQBK-UHFFFAOYSA-N |
| INCHI | 1S/C10H13NO2S2/c1-8(5-6-10(12)13)14-15-9-4-2-3-7-11-9/h2-4,7-8H,5-6H2,1H3,(H,12,13) |
| Isomeric SMILES | CC(CCC(=O)O)SSC1=CC=CC=N1 |
| Alternate CAS | 452072-22-9 |
| PubChem CID | 11536061 |
| Molecular Weight | 243.35 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Lipids and lipid-like molecules |
| Class | Fatty Acyls |
| Subclass | Fatty acids and conjugates |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Thia fatty acids |
| Alternative Parents | Pyridines and derivatives Heteroaromatic compounds Organic disulfides Sulfenyl compounds Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Thia fatty acid - Pyridine - Heteroaromatic compound - Organic disulfide - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Sulfenyl compound - Organoheterocyclic compound - Azacycle - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic oxide - Carbonyl group - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as thia fatty acids. These are fatty acid derivatives obtained by insertion of a sulfur atom at specific positions in the chain. |
| External Descriptors | Not available |
| Solubility | DMSO : 100 mg/mL (410.93 mM; Need ultrasonic) |
|---|---|
| Molecular Weight | 243.400 g/mol |
| XLogP3 | 2.000 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 6 |
| Exact Mass | 243.039 Da |
| Monoisotopic Mass | 243.039 Da |
| Topological Polar Surface Area | 101.000 Ų |
| Heavy Atom Count | 15 |
| Formal Charge | 0 |
| Complexity | 202.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Ying Li, Liya Niu, Chao Sun, Dongming Li, Zicong Zeng, Jianhui Xiao. (2023) Effect of Medium Chain Triglycerides on the Digestion and Quality Characteristics of Tea Polyphenols-Fortified Cooked Rice. Foods, 12 (23): (4366). [PMID:38231872] [10.3390/foods12234366] |
| 2. Yurong Bai, Mei Xiang, Zhenhua Zhou, Zhiqiang Mao, Fan Zhang. (2023) Engineering ATP activated reversible nanochannel for gating of ion transport. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2023.135100] |
| 3. Yun Li, Liya Niu, Leiyan Wu, Dongming Li, Chao Sun, Jianhui Xiao. (2023) Polyphenol-fortified extruded sweet potato starch vermicelli: Slow-releasing polyphenols is the main factor that reduces the starch digestibility. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:37866571] [10.1016/j.ijbiomac.2023.127584] |
| 4. Shiqin Sun, Yanshun Li, Ruixiang Sun, Luzhen Jiao, Shiwei Liu, Shitao Yu. (2023) Tailoring Zn-based diacidic functionalization of Deep eutectic solvent Catalyst: Green and efficient synthesis of ε-Caprolactam under mild conditions. FUEL, [PMID:] [10.1016/j.fuel.2023.129777] |
| 5. Yun Li, Liya Niu, Chao Sun, Jin Tu, Jianhui Xiao. (2023) Comparison of in vitro starch digestibility and structure of matcha-fortified starch vermicelli from different botanical sources. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, [PMID:37483079] [10.1002/jsfa.12875] |
| 6. Shuming Wu, Yanwei Li, Tinghong Wang, Hao Li, Xinna Wang, Lijuan Ma, Nazhen Zhang, Penghan Yue, Yanhui Li. (2023) Design and synthesis of dual functional porphyrin-based COFs as highly selective adsorbent and photocatalyst. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2023.144135] |
| 7. Songtao Liu, Rui Yan, Muhammad Humayun, Huanli Zhang, Yang Qu, Yingxue Jin. (2022) Pyropheophorbide-a/(001) TiO2 Nanocomposites with Enhanced Charge Separation and O2 Adsorption for High-Efficiency Visible-Light Degradation of Ametryn. MOLECULES, 27 (17): (5576). [PMID:36080345] [10.3390/molecules27175576] |
| 8. Wenjuan Li, Xingjiang Liu, Ailing Sun, Liuhe Wei, Rui Li, Hangyu He, Shaoli Yang, Shizhuo Wang, Yanfen Niu, Yuhan Li. (2021) Exploring piperazine for intrinsic weather-proof, robust and self-healable poly(urethane urea) toward surface and tire protection. POLYMER, [PMID:] [10.1016/j.polymer.2021.123829] |
| 9. Xiaoguang Pei, Weiyu Fan. (2021) Influence of Compound Modification of Oil Sands De-Oiled Asphalt and Polyphosphoric Acid on High- and Low-Temperature Performance of Styrene-Butadiene-Styrene-Modified Asphalt. Materials, 14 (4): (797). [PMID:33567546] [10.3390/ma14040797] |
| 10. Guoxing Yu, Chao Ma, Juan Li. (2019) Flame retardant effect of cytosine pyrophosphate and pentaerythritol on polypropylene. COMPOSITES PART B-ENGINEERING, [PMID:] [10.1016/j.compositesb.2019.107520] |
| 11. Wen Zhang, An Bu, Qingyuan Ji, Luofu Min, Song Zhao, Yuxin Wang, Jing Chen. (2019) pKa-Directed Incorporation of Phosphonates into MOF-808 via Ligand Exchange: Stability and Adsorption Properties for Uranium. ACS Applied Materials & Interfaces, [PMID:31409065] [10.1021/acsami.9b10920] |
| 12. Qiuxia Fu, Yang Si, Cheng Duan, Zishuo Yan, Lifang Liu, Jianyong Yu, Bin Ding. (2019) Highly Carboxylated, Cellular Structured, and Underwater Superelastic Nanofibrous Aerogels for Efficient Protein Separation. ADVANCED FUNCTIONAL MATERIALS, 29 (13): (1808234). [PMID:] [10.1002/adfm.201808234] |
| 13. Jinbin Liu, Jing Jiang, Yajun Bai, Tai-ping Fan, Ye Zhao, Xiaohui Zheng, Yujie Cai. (2018) Mimicking a New 2-Phenylethanol Production Pathway from Proteus mirabilis JN458 in Escherichia coli. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:29560727] [10.1021/acs.jafc.8b00627] |
| 14. Zhen Hu, Qing Shao, Mark G. Moloney, Xirong Xu, Dayu Zhang, Jun Li, Chunhua Zhang, Yudong Huang. (2017) Nondestructive Functionalization of Graphene by Surface-Initiated Atom Transfer Radical Polymerization: An Ideal Nanofiller for Poly(p-phenylene benzobisoxazole) Fibers. MACROMOLECULES, [PMID:] [10.1021/acs.macromol.6b02694] |
| 15. Miaomiao Han, Xiao Liu, Guangcheng Huang, Yadong Liu, Shengxiang Ji. (2016) Phosphoric acid doped polybenzimidazole as an heterogeneous catalyst for selective and efficient dehydration of saccharides to 5-hydroxymethylfurfural. RSC Advances, 6 (53): (47890-47896). [PMID:] [10.1039/C6RA00473C] |
| 16. Zhidong Zhang, Yingxin Liu, Xin Chen, Zhengzhong Shao. (2016) Multi-responsive polyethylene-polyamine/gelatin hydrogel induced by non-covalent interactions. RSC Advances, 6 (54): (48661-48665). [PMID:] [10.1039/C6RA05764K] |
| 17. Zhihu Yan, Caili Dai, Mingwei Zhao, Guang Zhao, Yuyang Li, Xuepeng Wu, Yifei Liu, Mingyong Du. (2015) Multi-Responsive Wormlike Micelles Based on N-alkyl-N-Methylpiperidinium Bromide Cationic Surfactant. JOURNAL OF SURFACTANTS AND DETERGENTS, 18 (5): (739-746). [PMID:] [10.1007/s11743-015-1718-2] |
| 18. Yan Zhihu, Dai Caili, Zhao Mingwei, Li Yuyang, Du Mingyong, Peng Dongxu. (2015) Study of pH-responsive surface active ionic liquids: the formation of spherical and wormlike micelles. COLLOID AND POLYMER SCIENCE, 293 (6): (1759-1766). [PMID:] [10.1007/s00396-015-3552-5] |
| 19. Lubiao Liu, Chuangmin Li, Qinhao Deng, Youwei Gan, Wei Liao. (2024) Study on the high-temperature performance and self-healing capability of asphalt modified with pyrolysis oil from waste tires and polyphosphoric acid. Case Studies in Construction Materials, [PMID:] [10.1016/j.cscm.2024.e03291] |
| 20. Li Minghua, Meng Xiumei, Sun Zhiyang, Zhu Chunjie, Ji Huiying. (2019) Effects of NADH Availability on 3-Phenyllactic Acid Production by Lactobacillus plantarum Expressing Formate Dehydrogenase. CURRENT MICROBIOLOGY, 76 (6): (706-712). [PMID:30963198] [10.1007/s00284-019-01681-0] |
