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· · COA & SDS available for every product · Same-day shipping on in-stock items SB 452533 - Moligand™, ≥98%(HPLC) , Channel blocker of TRPV1, CAS No.459429-39-1, Channel blocker of TRPV1
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC) Synonyms
n-(2-bromophenyl)-n'-[2-[ethyl(3-methylphenyl)amino]ethyl]urea | N-(2-Bromophenyl)-N'-[2-[ethyl(3-methylphenyl)amino]ethyl]-urea | AKOS024457514 | MS-26098 | SB452533 | SB-452533 | N-[2-Bromophenyl]-N'-[2-(N''-ethyl-N''-(3-methylphenyl)amino)ethyl]urea |
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥98%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
n-(2-bromophenyl)-n'-[2-[ethyl(3-methylphenyl)amino]ethyl]urea | N-(2-Bromophenyl)-N'-[2-[ethyl(3-methylphenyl)amino]ethyl]-urea | AKOS024457514 | MS-26098 | SB452533 | SB-452533 | N-[2-Bromophenyl]-N'-[2-(N''-ethyl-N''-(3-methylphenyl)amino)ethyl]urea |
Specifications & Purity
Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms
Potent TRPV1 antagonist against capsaicin (pKb= 7.7), noxious heat and acid-mediated (pIC50= 7.0) receptor activation (pKi= 6.22 at the recombinant hTRPV1 receptor). Exhibits analgesic properties.
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
CHANNEL BLOCKER
Mechanism of action
Channel blocker of TRPV1
Names and Identifiers Pubchem Sid Url
https://pubchem.ncbi.nlm.nih.gov/substance/504764960
Canonical Smiles
CCN(CCNC(=O)NC1=CC=CC=C1Br)C2=CC=CC(=C2)C
IUPAC Name
1-(2-bromophenyl)-3-[2-(N-ethyl-3-methylanilino)ethyl]urea
InChIKey
IFJYEGJUQIBBQV-UHFFFAOYSA-N
INCHI
1S/C18H22BrN3O/c1-3-22(15-8-6-7-14(2)13-15)12-11-20-18(23)21-17-10-5-4-9-16(17)19/h4-10,13H,3,11-12H2,1-2H3,(H2,20,21,23)
Isomeric SMILES
CCN(CCNC(=O)NC1=CC=CC=C1Br)C2=CC=CC(=C2)C
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Benzenoids Class Benzene and substituted derivatives Subclass N-phenylureas Intermediate Tree Nodes Not available Direct Parent N-phenylureas Alternative Parents Dialkylarylamines Aniline and substituted anilines Aminotoluenes Bromobenzenes Aryl bromides Ureas Organobromides Organic oxides Hydrocarbon derivatives Carbonyl compounds Molecular Framework Aromatic homomonocyclic compounds Substituents N-phenylurea - Aminotoluene - Aniline or substituted anilines - Dialkylarylamine - Tertiary aliphatic/aromatic amine - Bromobenzene - Halobenzene - Toluene - Aryl bromide - Aryl halide - Urea - Tertiary amine - Amine - Organonitrogen compound - Organobromide - Organohalogen compound - Organooxygen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Aromatic homomonocyclic compound Description This compound belongs to the class of organic compounds known as n-phenylureas. These are compounds containing a N-phenylurea moiety, which is structurally characterized by a phenyl group linked to one nitrogen atom of a urea group. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 37.63, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 3.76, Max Conc. mM: 10 with gentle warming Molecular Weight 376.300 g/mol XLogP3 4.200 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2 Rotatable Bond Count 6 Exact Mass 375.095 Da Monoisotopic Mass 375.095 Da Topological Polar Surface Area 44.400 Ų Heavy Atom Count 23 Formal Charge 0 Complexity 366.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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