SKA 121 - Moligand™, ≥98%(HPLC) , Activator of K Ca3.1, CAS No.1820708-73-3, Activator of K Ca3.1

CAS: 1820708-73-3 Cat. No.: S287446 Formula: C₁₂H₁₀N₂O Molecular Weight: 198.23 PubChem CID: 91827362

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

5-Methylnaphth[2,1-d]oxazol-2-amine | SKA-121 | 5-Methylnaphth[2,1-d]oxazol-2-amine, 5-Methylnaphtho[2,1-d]oxazol-2-amine | SKA121 | 5-methyl-naphth[2,1-d]oxazol-2-amine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Product description：

SKA-121 is a selective KCa3.1 activator. SKA-121 exhibits EC50s of 109 nM and 4.4 μM for KCa3.1 and KCa2.3, respectively.

Specifications

Synonyms

5-Methylnaphth[2,1-d]oxazol-2-amine | SKA-121 | 5-Methylnaphth[2,1-d]oxazol-2-amine, 5-Methylnaphtho[2,1-d]oxazol-2-amine | SKA121 | 5-methyl-naphth[2,1-d]oxazol-2-amine

Specifications & Purity

Moligand™, ≥98%(HPLC)

Biochemical and Physiological Mechanisms

Positive allosteric modulator of KCa3.1 (intermediate-conductance Ca2+-activated potassium) channels (EC50= 109 nM). Displays 40-fold selectivity for KCa3.1 over KCa2.3, and 200 to 400-fold selectivity over KVand NaVchannels. Potentiates bradykinin-induce

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ACTIVATOR

Mechanism of action

Activator of K Ca3.1

Purity

≥98%(HPLC)

Names and Identifiers

Canonical Smiles

CC1=CC2=C(C3=CC=CC=C13)OC(=N2)N

IUPAC Name

5-methylbenzo[g][1,3]benzoxazol-2-amine

InChIKey

JEGUERWMMMQFJV-UHFFFAOYSA-N

INCHI

1S/C12H10N2O/c1-7-6-10-11(15-12(13)14-10)9-5-3-2-4-8(7)9/h2-6H,1H3,(H2,13,14)

Isomeric SMILES

CC1=CC2=C(C3=CC=CC=C13)OC(=N2)N

PubChem CID

91827362

MeSH Entry Terms

5-methylnaphtho(2,1-d)oxazol-2-amine;SKA-121

Molecular Weight

198.23

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Naphthalenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Naphthalenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Naphthalenes
• Alternative Parents: Benzoxazoles Oxazoles Heteroaromatic compounds Oxacyclic compounds Azacyclic compounds Primary amines Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Naphthalene - Benzoxazole - Azole - Oxazole - Heteroaromatic compound - Azacycle - Organoheterocyclic compound - Oxacycle - Primary amine - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

KCNN4 Tchem Intermediate conductance calcium-activated potassium channel protein 4 (1 Activities)

Discover Target: KCNN4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 19.82, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 9.91, Max Conc. mM: 50
• Molecular Weight: 198.220 g/mol
• XLogP3: 3.000
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 198.079 Da
• Monoisotopic Mass: 198.079 Da
• Topological Polar Surface Area: 52.100 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 246.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1