≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
SR-717 lithium SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity.
Targets
STING (in ISG-THP1 (WT) cells); STING (in ISG-THP1 (cGAS KO) cells) 2.1 μM(EC50); 2.2 μM(EC50)
| alogp | 1.765 |
|---|---|
| hbd_count | 1 |
| rotatable_bond | 5 |
| Pubchem Sid | 504773566 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773566 |
| Canonical Smiles | [Li+].C1=CC(=NN=C1C(=O)NC2=CC(=C(C=C2C(=O)[O-])F)F)N3C=CN=C3 |
| IUPAC Name | lithium;4,5-difluoro-2-[(6-imidazol-1-ylpyridazine-3-carbonyl)amino]benzoate |
| InChIKey | ODSAJRWPLSVEHJ-UHFFFAOYSA-M |
| INCHI | 1S/C15H9F2N5O3.Li/c16-9-5-8(15(24)25)12(6-10(9)17)19-14(23)11-1-2-13(21-20-11)22-4-3-18-7-22;/h1-7H,(H,19,23)(H,24,25);/q;+1/p-1 |
| PubChem CID | 139434658 |
| Molecular Weight | 351.19 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Benzene and substituted derivatives |
| Subclass | Anilides |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Aromatic anilides |
| Alternative Parents | Halobenzoic acids 4-halobenzoic acids 3-halobenzoic acids Benzoic acids Benzoyl derivatives Fluorobenzenes Pyridazines and derivatives Fatty acids and conjugates Vinylogous amides Heteroaromatic compounds Azoles Carboxylic acid salts Organic metal halides Organic lithium salts Monocarboxylic acids and derivatives Carboxylic acids Carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organofluorides Organic zwitterions Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Aromatic anilide - Halobenzoic acid - 4-halobenzoic acid - 3-halobenzoic acid - Halobenzoic acid or derivatives - 4-halobenzoic acid or derivatives - 3-halobenzoic acid or derivatives - Benzoic acid - Benzoic acid or derivatives - Benzoyl - Halobenzene - Fluorobenzene - Fatty acid - Pyridazine - Heteroaromatic compound - Vinylogous amide - Azole - Carboxylic acid salt - Carboxamide group - Organic metal halide - Organic lithium salt - Azacycle - Organic alkali metal salt - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organic salt - Organic zwitterion - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as aromatic anilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with an aromatic group. They have the general structure RNC(=O)R', where R= benzene, and R = aryl group. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 A2621076 | Certificate of Analysis | Jan 27, 2026 | S412586 |
| G2220085 | Certificate of Analysis | May 09, 2025 | S412586 |
| G2220137 | Certificate of Analysis | May 09, 2025 | S412586 |
| G2220139 | Certificate of Analysis | May 09, 2025 | S412586 |
| G2220140 | Certificate of Analysis | May 09, 2025 | S412586 |
| Solubility | Solubility (25°C) In vitro DMSO: 35 mg/mL (99.66 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| dmso_mg_max_solubility | 40 |
| dmso_mM_max_solubility | 113.898459523335 |
| water_mg_max_solubility | ＜1 |
| Molecular Weight | 351.200 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 4 |
| Exact Mass | 351.076 Da |
| Monoisotopic Mass | 351.076 Da |
| Topological Polar Surface Area | 113.000 Ų |
| Heavy Atom Count | 26 |
| Formal Charge | 0 |
| Complexity | 518.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
| 1. Tu Maopu, Deng Xiaoyu, Zhou Zhiyong, Li Xiaodong, Mao Shengxun, Lai Bin, Pang Lisong, Zhong Qilin, Cao Jiaqing, Liu Haipeng, Ouyang Xi. (2026) Multifunctional copper-based nanoparticles potentiate colorectal cancer immunotherapy via synergistic metabolic remodeling and cGAS-STING pathway activation. JOURNAL OF NANOBIOTECHNOLOGY, [PMID:41796309] [10.1186/s12951-026-04267-8] |
