Src Inhibitor 3 - 10mM in DMSO , CAS No.2380027-49-4

CAS: 2380027-49-4 Cat. No.: S655271 Molecular Weight: 671.12 PubChem CID: 139600340

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Src Inhibitor 3 is a potent, orally active c-terminal Src kinase (CSK) with IC 50 values below 3 nM and 4 nM in CSK HTRF and Caliper assay, respectively. Src Inhibitor 3 shows the ability to increase T cell proliferation induced by T cell receptor signaling

In Vivo

Src Inhibitor 3 reduces inhibitory LCK phosphorylation in vivo upon oral dosing and shows the ability to enhance T cell activation in response to antigen stimulation . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: <3 nM (c-terminal Src kinase in CSK HTRF assay), 4 nM (c-terminal Src kinase in Caliper assay)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Src Inhibitor 3 is a potent, orally active c-terminal Src kinase (CSK) with IC 50 values below 3 nM and 4 nM in CSK HTRF and Caliper assay, respectively. Src Inhibitor 3 shows the ability to increase T cell proliferation induced by T cell receptor signali

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CC(C)(CC(=O)N1CCC(CC1)N2C3=C(C=C(C=C3)F)C(=N2)C(=O)NC4=CC(=C(C=C4)NC(=O)C5=C6C=CC(=CN6N=C5)OC)Cl)C#N
• PubChem CID: 139600340
• Molecular Weight: 671.12

Associated Targets(Human)

CSK Tchem Tyrosine-protein kinase CSK (1 Activities)

Discover Target: CSK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)