Sulfameter - Moligand™, ≥98% , CAS No.651-06-9

CAS: 651-06-9 Cat. No.: S128350 Molecular Weight: 280.3 Beilstein Registry Number: 621130 EC Number: 211-480-8 PubChem CID: 5326
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GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
Sulfamethoxydine | I-2586 | sulfameter | Dairena | NSC-757874 | Kiron | Solfametossidiazina [DCIT] | DTXCID003613 | Durenat | GTPL12641 | SULFAMETER [ORANGE BOOK] | 2-(4-Aminobenzenesulfonamido)-5-methoxypyrimidine | KBio2_004197 | KBio3_002485 | Longasul
Storage
Room temperature
Shipped In
Normal
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Size
Status
Price
Qty
1g
S128350-1g
2
$9.90
5g
S128350-5g
2
$10.90
25g
S128350-25g
3

$14.90

$22.90
Save $8.00 (34.93%)
100g
S128350-100g
3

$30.90

$46.90
Save $16.00 (34.12%)
500g
S128350-500g
2

$107.90

$161.90
Save $54.00 (33.35%)
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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 18 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Sulfameter is a sulfonamide antibiotic used as a leprostatic agent and to treat urinary tract infections. It has been investigated as a potential therapy for chloroquine-resistant malaria during pregnancy.

Specifications

Synonyms
Sulfamethoxydine | I-2586 | sulfameter | Dairena | NSC-757874 | Kiron | Solfametossidiazina [DCIT] | DTXCID003613 | Durenat | GTPL12641 | SULFAMETER [ORANGE BOOK] | 2-(4-Aminobenzenesulfonamido)-5-methoxypyrimidine | KBio2_004197 | KBio3_002485 | Longasul
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
Sulfameter is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bact
Storage
Room temperature
Shipped In
Normal
Grade
Moligand™
Purity
≥98%
Product Properties
ALogP0.4
Names and Identifiers
Pubchem Sid504750867
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504750867
Canonical SmilesCOC1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
IUPAC Name4-amino-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide
InChIKeyGPTONYMQFTZPKC-UHFFFAOYSA-N
INCHI1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
Isomeric SMILES COC1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
PubChem CID 5326
Molecular Weight 280.3
Beilstein 621130

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassBenzene and substituted derivatives
SubclassBenzenesulfonamides
Intermediate Tree Nodes Not available
Direct ParentAminobenzenesulfonamides
Alternative Parents Benzenesulfonyl compounds  Aniline and substituted anilines  Alkyl aryl ethers  Pyrimidines and pyrimidine derivatives  Organosulfonamides  Heteroaromatic compounds  Aminosulfonyl compounds  Azacyclic compounds  Primary amines  Organopnictogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Aminobenzenesulfonamide - Benzenesulfonyl group - Aniline or substituted anilines - Alkyl aryl ether - Pyrimidine - Organosulfonic acid amide - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Aminosulfonyl compound - Heteroaromatic compound - Organoheterocyclic compound - Azacycle - Ether - Organic oxygen compound - Organic oxide - Amine - Organic nitrogen compound - Organopnictogen compound - Primary amine - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
External Descriptors sulfonamide - pyrimidines - sulfonamide antibiotic
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
PTH1R Tclin Parathyroid hormone receptor (47172 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot NumberCertificate TypeDateItem
I1423120Certificate of AnalysisApr 15, 2026 S128350
C1418009Certificate of AnalysisOct 14, 2025 S128350
C2111108Certificate of AnalysisDec 10, 2024 S128350
C2111109Certificate of AnalysisDec 10, 2024 S128350
C2111110Certificate of AnalysisDec 10, 2024 S128350
I2504572Certificate of AnalysisJul 06, 2024 S128350
A2419645Certificate of AnalysisNov 22, 2023 S128350
A2419646Certificate of AnalysisNov 22, 2023 S128350
A2419647Certificate of AnalysisNov 22, 2023 S128350
A2419648Certificate of AnalysisNov 22, 2023 S128350
K2228554Certificate of AnalysisOct 24, 2022 S128350
K2228739Certificate of AnalysisOct 24, 2022 S128350
K2228740Certificate of AnalysisOct 24, 2022 S128350
K2228741Certificate of AnalysisOct 24, 2022 S128350
K2228745Certificate of AnalysisOct 24, 2022 S128350

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Chemical and Physical Properties
Sensitivitylight sensitive
Melt Point(°C)214-216°C
Molecular Weight280.310 g/mol
XLogP30.400
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass280.063 Da
Monoisotopic Mass280.063 Da
Topological Polar Surface Area116.000 Ų
Heavy Atom Count19
Formal Charge0
Complexity368.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Meiling Ping, Wenchao Lv, Chen Yang, Qian Chen, Zongwen Wang, Fengfu Fu.  (2023)  A Paper-Based Multicolor Colorimetric Aptasensor for the Visual Determination of Multiple Sulfonamides Based on Aptamer-Functionalized Magnetic Beads and NADH–Ascorbic Acid-Mediated Gold Nanobipyramids.  Chemosensors,  11  (7): (386).  [PMID:] [10.3390/chemosensors11070386]
2. Zongwen Wang, Xiating Li, Feng Zhang, Yu Gao, Jintian Cheng, FengFu Fu.  (2023)  Regulating the Growth Rate of Gold Nanobipyramids via a HCl-NADH-Ascorbic Acid System toward a Dual-Channel Multicolor Colorimetric Immunoassay for Simultaneously Screening and Detecting Multiple Sulfonamides.  ANALYTICAL CHEMISTRY,      [PMID:37382204] [10.1021/acs.analchem.3c01928]
3. Vinay Naithani, Soumia Cheddah, Kaige Yang, Zihang Xia, Weiwei Wang, Yan Wang, Chao Yan.  (2023)  Preparation of open tubular capillary column covalently coated with polystyrene sulfonate with 4,4′-Azobis(4-cyanopentanoyl chloride) as polymerization initiator for electrochromatographic separation of alkaloids, sulfonamides, and peptides.  JOURNAL OF SEPARATION SCIENCE,      [PMID:36929049] [10.1002/jssc.202200711]
4. Yuehua Deng, Wei Luo, Zhiyong Zheng, Guixuan Wei, Shiyuan Liu, Yanbin Jiang, Huaiyu Yang.  (2023)  Prediction of co-amorphous formation using non-bonded interaction energy: Molecular dynamic simulation and experimental validation.  CHEMICAL ENGINEERING SCIENCE,      [PMID:] [10.1016/j.ces.2023.118618]
5. Yanping He, Jingrui Zhang, Ruifen Tian, Yuying Lu, Ling Pan, Yuzhong Zhang.  (2023)  Selected ssDNA aptamers–graphene oxide-based fluorescent biosensor to detect sulfameter in milk.  LUMINESCENCE,  38  (5): (518-526).  [PMID:36882911] [10.1002/bio.4473]
6. Bin Han, Wenbin Li, Yang Shen, Ruifang Li, Mengyi Wang, Zhijia Zhuang, Yikai Zhou, Tao Jing.  (2022)  Improving the sensitivity and selectivity of sulfonamides electrochemical detection with double-system imprinted polymers.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:36572315] [10.1016/j.scitotenv.2022.161173]
7. Zhangsong Jiang, Xiangfeng Huang, Qiaofeng Wu, Mi Li, Qili Xie, Zuwen Liu, Xiaoming Zou.  (2022)  Adsorption of sulfonamides on polyamide microplastics in an aqueous solution: behavior, structural effects, and its mechanism.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2022.140452]
8. Lizhen Qiao, Yuan Tao, Wang Yao, Jieyu Zhao, Yang Yan.  (2022)  A magnetic ionic liquid based vortex-assisted dispersive liquid-liquid microextraction coupled with back-extraction for the enrichment of fluoroquinolone antibiotics.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:35759827] [10.1016/j.jpba.2022.114903]
9. Qin Peige, Han Lizhen, Zhang Xiaowan, Li Mengyuan, Li Dan, Lu Minghua, Cai Zongwei.  (2021)  MIL-101(Fe)-derived magnetic porous carbon as sorbent for stir bar sorptive-dispersive microextraction of sulfonamides.  MICROCHIMICA ACTA,  188  (10): (1-11).  [PMID:34523015] [10.1007/s00604-021-04993-w]
10. Yunbo Liu, Xuemei Zhang, Jinhua Deng, Yong Liu.  (2021)  A novel CNTs-Fe3O4 synthetized via a ball-milling strategy as efficient fenton-like catalyst for degradation of sulfonamides.  CHEMOSPHERE,      [PMID:33773319] [10.1016/j.chemosphere.2021.130305]
11. Yinming Fan, Guolong Zeng, Xiaoguo Ma.  (2020)  Effects of prepolymerization on surface molecularly imprinted polymer for rapid separation and analysis of sulfonamides in water.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:32182497] [10.1016/j.jcis.2020.03.027]
12. Minghuo Wu, Lin Fu, Yufeng Hu, Jingyun Su, Siyuan Jing, Hao Zhou, Jingjing Zhan.  (2018)  Multiplex On-Bead Isotope Dimethyl Labeling Coupled with Liquid Chromatography–High-Resolution Mass Spectrometry for Quantitative Analysis of Sulfonamides in Estuarine Ice.  ANALYTICAL CHEMISTRY,      [PMID:30221932] [10.1021/acs.analchem.8b03220]
13. Dandan Qin, Wangyang Lu, Zhexin Zhu, Nan Li, Tiefeng Xu, Gangqiang Wang, Wenxing Chen.  (2017)  Free Channel Formation around Graphitic Carbon Nitride Embedded in Porous Polyethylene Terephthalate Nanofibers with Excellent Reusability for Eliminating Antibiotics under Solar Irradiation.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.7b02800]
14. Chengjiang Zhang, Xialin Luo, Tianfu Wei, Yufei Hu, Gongke Li, Zhuomin Zhang.  (2017)  Acylhydrazone bond dynamic covalent polymer gel monolithic column online coupling to high-performance liquid chromatography for analysis of sulfonamides and fluorescent whitening agents in food.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:28890268] [10.1016/j.chroma.2017.09.002]
15. Dandan Qin, Wangyang Lu, Xiyi Wang, Nan Li, Xia Chen, Zhexin Zhu, Wenxing Chen.  (2016)  Graphitic Carbon Nitride from Burial to Re-emergence on Polyethylene Terephthalate Nanofibers as an Easily Recycled Photocatalyst for Degrading Antibiotics under Solar Irradiation.  ACS Applied Materials & Interfaces,      [PMID:27617344] [10.1021/acsami.6b07680]
16. Ruiying Zhu, Hong Ma, Xuan Luo, Li Zhao, Xiaofang Pan, Binfei Yang, Xiaochun Wu, Xiaobo Gong.  (2024)  Defective cobalt-nitrogen dual-doped carbon materials for enhanced tetracycline hydrochloride degradation in flow-through electro-Fenton-membrane system.  PROCESS SAFETY AND ENVIRONMENTAL PROTECTION,      [PMID:] [10.1016/j.psep.2024.12.073]
17. Yue Zhou, Yuanyuan Jiang, Xiangyu Chen, Hongchen Long, Mao Zhang, Zili Tang, Yufang He, Lei Zhang, Tao Le.  (2024)  Enhanced Sensitivity and Accuracy of Tb3+-Functionalized Zirconium-Based Bimetallic MOF for Visual Detection of Malachite Green in Fish.  Foods,  13  (17): (2855).  [PMID:39272620] [10.3390/foods13172855]
18. Huiting Feng, Yuxin Yang, Ruiling Li, Yuting Yang, Zongwen Wang, FengFu Fu, Yue Lin.  (2026)  Employment of mixed aptamers and gold nanobipyramids toward a paper-based aptasensor for simultaneously visual screening and accurate detection of eight sulfonamides.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:] [10.1016/j.saa.2026.127574]
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