T807 - 10mM in DMSO , CAS No.1415379-56-4

CAS: 1415379-56-4 Cat. No.: T656719 Molecular Weight: 263.27 EC Number: 807-515-7 PubChem CID: 71059746

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

T807 a novel tau positron emission tomography (PET) tracer.

In Vitro

Aggregated tau protein is a major neuropathological substrate central to the pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD). In vitro autoradiography results show that [ 18 F]T807 exhibits strong binding to PHF-tau positive human brain sections (K d =14.6 nM). A comparison of autoradiography and double immunohistochemical staining of PHF-tau and Ab on adjacent sections demonstrates that [ 18 F]T807 binding colocalizes with immunoreactive PHF-tau pathology, but does not highlight Ab plaques. [ 18 F]T807 strongly binds to tau lesions primarily made of paired helical filaments in Alzheimer’s brains e.g. intra and extraneuronal tangles and dystrophic neurites. [ 18 F]T807 off-target binding to neuromelanin- and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions is identified. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

[ 18 F]T807 is able to cross the blood–brain barrier and ished out quickly in mice model. [ 18 F]T807 clears rapidly from the brain, with activity values decreasing from 4.43% ID/g at 5 minutes to 0.62% ID/g at 30 minutes. Kidney elimination is a significant clearance pathway, resulting in a maximum tracer concentration of 14.99% ID/g in the kidneys at 5 minutes, which decreases to 5.52% ID/g at 30 minutes. The accumulation of activity in muscle and bone remain relatively low throughout the PET scan . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

T807 a novel tau positron emission tomography (PET) tracer.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C1=CC2=C(C=C1C3=CN=C(C=C3)F)NC4=C2C=NC=C4
• Alternate CAS: 1415379-56-4
• PubChem CID: 71059746
• MeSH Entry Terms: (18)AV-1451;(18)F-flortaucipir;(18F)1451;(18F)AV-1451;(18F)flortaucipir;(18F)T807 compound;(F-18)-AV-1451;(F-18)T807;7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole;AV-1451;AV1451;F-18-AV-1451;flortaucipir;flortaucipir (18F);flortaucipir (F 18);flortaucip
• Molecular Weight: 263.27