Tezacaftor-d4 - ≥97% , CAS No.1961280-24-9

CAS: 1961280-24-9 Cat. No.: T648965 Molecular Weight: 524.52

GRADE & PURITY ≥97%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Tezacaftor-d4 (VX-661-d4) is the deuterium-labeled Tezacaftor ( HY-15448 ), a F508del CFTR corrector. Tezacaftor helps CFTR protein reach the cell surface.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Specifications & Purity

≥97%

Biochemical and Physiological Mechanisms

Tezacaftor-d4 (VX-661-d4) is the deuterium-labeled Tezacaftor ( HY-15448 ), a F508del CFTR corrector. Tezacaftor helps CFTR protein reach the cell surface.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥97%

Names and Identifiers

• Canonical Smiles: FC1=C(C=C2C(N(C(C(C)(C)CO)=C2)C[C@@H](O)CO)=C1)NC(C3(C4=CC=C(OC(F)(O5)F)C5=C4)C([2H])([2H])C3([2H])[2H])=O
• Molecular Weight: 524.52